| 益心口服液药物预处理对大鼠心肌缺血再灌注损伤的影响 |
| 投稿时间：2000-12-23 点此下载全文 |
| 引用本文：卫洪昌,王秀薇,吕嵘,程金波,朱晓梅,吴倩,章忱.益心口服液药物预处理对大鼠心肌缺血再灌注损伤的影响[J].药学实践杂志,2001,(3):157~159 |
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| 基金项目:上海市卫生局课题(98Z015);上海市科委课题(99ZB14045) |
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| 中文摘要:目的 研究益心口服液药物预处理对大鼠心肌缺血再灌注损伤的保护作用。方法 设正常、假手术、缺血再灌注、经典缺血预处理及益心口服液组,观察各组大鼠的血流动力学以及心肌细胞内钙离子浓度变化。结果 经典预处理组、益心口服液组再灌注 60min后LVSP、±dp/dt均显着高于缺血再灌组(P<0.05);预处理组再灌注 60min后LVSP、±dp/dt均显着高于益心口服液组(P<0.05).经典预处理组、益心口服液组钙离子浓度低于缺血再灌注组(P<0.05),益心口服液组钙离子浓度高于经典预处理组(P<0.05).结论 益心口服液预处理对大鼠心肌缺血再灌注损伤具有一定保护作用,部分机制可能是减轻心肌细胞内钙离子超载所带来的损害。 |
| 中文关键词:益心口服液 血流动力学 细胞内钙离子 |
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| Pharmacological preconditioning of Yixin Oral Liquid (YOL) during myocardium ischemia and reperfusion in rat |
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| Abstract:OBJECTIVE To investigate the protective mechanism of YOL on ischemia/reperfusion (I/R) myocardium.METHODS48 male SD rats,weighting (260±30)g,were divided into 6 groups.They were normal control,I/R,classical ischemic precondition(C-IPC),sham-operated,Isosorbide dinitrate and YOL.The intracelular calcium concentration of the cardiomyocyte and hemodynamic changes were measured in all groups.RESULTS LVSP、±dp/dt in C-IPC and YOL tread with ischemia 30 min and followed by reperfusion 60 min were obviously higher in I/R(P<0.05)while LVSP、±dp/dt of C-IPC was alsodefinitely high compared with YOL(P<0.05).The intracel ular calcium concentrat ion in C-IPC and YOL were lower in I/R(P<0.05),while[Ca2+]I of YOL was increased in C-IPC (P<0.05).CONCLUSIONS Yix in oral Liquid(YOL)precondit ioning can protect the myocardium from I/R.The possible protective mechanism may be due to decrease calcium overload in cardiomyocyte. |
| keywords:YOL hemodynamics calcium |
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