| 双戊烯对替硝唑透皮吸收促进作用的研究 |
| 投稿时间：2000-10-12 点此下载全文 |
| 引用本文：尚北城,方丽莎,贺建国,韦丽佳,张松.双戊烯对替硝唑透皮吸收促进作用的研究[J].药学实践杂志,2001,(2):89~91 |
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| 中文摘要:目的 研究双戊烯对替硝唑的促透效果,为透皮促进剂的选择提供参考。方法 通过离体小鼠皮肤渗透释药实验,测定含不同浓度双戊烯和氮酮对替硝唑溶液促透效果。结果 不同浓度促透剂对替硝唑的透皮吸收促进效果大小顺序为3%双戊烯>2 %双戊烯≈4%氮酮>3%氮酮。结论 3%双戊烯对替硝唑溶液有显著的透皮促进作用,与其他浓度的双戊烯和氮酮相比具有显著差异(P <0.05)。 |
| 中文关键词:双戊烯 氮酮 透皮促进剂 透皮吸收 |
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| Enhancement effect of dipentene in the transdermal absorption of tinidazole |
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| Abstract:OBJECTIVE To study the enhancement effect of dipentene in the transdermal absorption of tinidazole.METHODS In vitro,using side-by-side diffusion cells determines the diffusion of tinidazole across excised mouse skin to compare the enhancement effect of dipentene with Azone at different concentrations in the transdermal absorption of tinidazole.RESULTS Enhancement effects at different concentrations were following 3% dipentene>2% dipentene≈4%Azone>3% Azone.CONCLUSION It is showed that various concentrations of transdermal enhancers could promote absorption of tinidazole in different degrees and 4% Azone and 3% dipentene are the most effective. |
| keywords:dipentene Azone transdermal enhancer transdermal absorption |
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