| 地塞米松脂质体质量控制方面的研究 |
| 投稿时间：2000-07-03 点此下载全文 |
| 引用本文：郑永红,全东琴.地塞米松脂质体质量控制方面的研究[J].药学实践杂志,2001,(2):86~88 |
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| 中文摘要:目的 地塞米松脂质体是本院研究的新剂型,本文从质量控制的主要方面,对其进行了研究。方法 通过负染法,观察在透射电子显微镜下的形态;采用紫外系数倍率法测定地塞米松的含量;用MACROSEP首次测定了包封率。结果 地塞米松脂质体属于胶体分散系范围,符合质量控制的要求;在4～52μg/ml浓度范围内线性关系良好,回收率在98.28%～99.71%之间;包封率均在80%以上,包封效果良好。结论 本文方法具有准确、快速、重现性好等特点,便于药厂和医院的快检 |
| 中文关键词:地塞米松 脂质体 系数倍率法 包封率 |
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| Studies on quality control of dexamethasone liposomes |
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| Abstract:OBJECTIVE To study the main aspects of quality control of dexamethasone liposomes.METHODS The structure of liposomes was studied with negative staining method of TEM.K-ratio spectrophotometry was used to determine the content,and the Macrosep was used to seperate the entrapped from free drugs.RESULTS An excellent linear relationship was obtained with the range of 4～52μg/ml,the average recovery percent was between 98.28%～99.71%.The entrapment efficiency was one of the important parameters of liposomes quality control.It was related with the clinical effect directly,the entrapment efficiency was more than 80%.CONCLUSION This method is accurate,quick and reproducible. |
| keywords:dexamethasone liposome k-ratio spectrophotometry entrapment efficiency |
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