| 阿司匹林肠溶衣片的溶出度及释放度研究 |
| 投稿时间：1999-09-06 点此下载全文 |
| 引用本文：袭荣刚,王晓波,李忠亮,姚文,李健.阿司匹林肠溶衣片的溶出度及释放度研究[J].药学实践杂志,2000,(2):83~85 |
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| 中文摘要:目的 研究不同厂家阿司匹林肠溶衣片的溶出度及释放度。方法 本文采用转篮法对国内4个厂家的阿司匹林肠溶衣片进行体外溶出度、释放度测定。结果 4个厂家的某一批号产品的溶出参数分别为:980222(T5019.3±0.8,Td22.7±1.1,m2.0±0.2);980407(T5013.2±0.5,Td17.5±0.6,m3.2±0.1);981005(T5026.3±0.2,Td32.0±0.2,m1.5±0.1);981225(T5019.4±0.3Td25.2±0.1,m1.8±0.1).结论 不同厂家片剂之间,其溶出参数(T50,Td,m)有显着差别(P<0.001)。 |
| 中文关键词:阿司匹林肠溶片 溶出度 释放度 高效液相色谱法 |
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| Studies on the dissolubility and liberation of aspirin enteric coatel tablet |
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| Abstract:OBJECTIVE To study the dissolubility and the liberation of aspirin enteric coatel tablet.METHODS Using basket meothod,the dissolubility and the liberation of aspirin enteric coatel tablets from different companies were determined.RESULTS The dissolution processed statistically:980222(T5019.3±0.8,Td22.7±1.1,m2.0±0.2);980407(T5013.2±0.5,Td17.5±0.6,m3.2±0.1);981005(T5026.3±0.2,Td32.0±0.2,m1.5±0.1);981225(T5019.4±0.3Td25.2±0.1,m1.8±0.1). CONCLUSION The results showed that there were significant differences in dissolubility and the liberation among the product(P<0.001). |
| keywords:aspirin enteric coatel tablet liberation dissolubility HPLC |
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