| 米托蒽醌缓释复合人工骨体外释放度考察 |
| 投稿时间：1999-02-01 点此下载全文 |
| 引用本文：景利,曾仁杰,孙伟张,刘清.米托蒽醌缓释复合人工骨体外释放度考察[J].药学实践杂志,1999,(5):298~299 |
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| 中文摘要:目的 考察羟基磷灰石陶瓷为药物载体、蜂蜡为阻滞剂制备的不同浓度蜂蜡包裹的米托蒽醌缓释复合人工骨(DHAQ-PHA-WAX)与未包裹蜂蜡的米托蒽醌人工骨(DHAQ-PHA)的体外释药规律。方法 可见分光光度法于660nm处测定包裹与未包裹蜂蜡的米托蒽醌-人工骨每天的释药量。结果 DHAQ-PHA与DHAQ-PHA-WAX的溶出速率有显着差异(P<005)。结论 DHAQ-PHA-WAX可有效地控制药物的释放。 |
| 中文关键词:羟基磷灰石复合人工骨 蜂蜡 米托蒽醌 溶出速率 |
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| Study on the dissolution of mitoxantrone in mitoxantron-hydroxylapatite ceramic composites in vitro |
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| Abstract:OBJECTIVE To investigate the drug-releasing regularity in vitro of variable concentration mitoxantrone,which wax in a matoxantrone hydroxylapatite ceramic composite encapsulated with wax (DHAQ-PHA-WAX) and DHAQ-PHA without the wax.hydroxylapatite ceramic was used as drug carrier and wax as inhibitor. METHODS The released drug concentration per-day was determined by visible spectrometry at λ =660nm. RESULTS There was a significant difference (P<0.05) between DHAQ-PHA dissolution velocity and DHAQ-PHA-WAX. CONCLUTION Releasing of DHAQ could be controlled with DHAQ-PHA-WAX. |
| keywords:hydroxylapatite ceramic composite wax mitoxantrone rate of drug-releasing |
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