| 多元回归分光光度法测定复方乙酰水杨酸片中的非那西丁和咖啡因的含量 |
| 投稿时间：1998-07-07 点此下载全文 |
| 引用本文：方洪壮,雷力力,刘兴宝.多元回归分光光度法测定复方乙酰水杨酸片中的非那西丁和咖啡因的含量[J].药学实践杂志,1999,(1):31~33 |
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| 中文摘要:目的 探讨复方乙酰水杨酸片中非那西丁和咖啡因的含量测定方法。方法 在乙醇中溶解样品,用0.2mol/LNaOH水解乙酰水杨酸后,以pH6.5磷酸盐缓冲液为溶剂进行定量,采用多元回归分光光度法。结果 非那西丁和咖啡因的平均回收率分别为99.8%和99.9%,RSD为0.72%和0.52%。结论 样品的测定结果同部颁标准法比较在准确度上无显着差异。 |
| 中文关键词:多元回归分光光度法 复方乙酰水杨酸片 非那西丁 咖啡因 含量测定 |
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| Determination of phenacetin and caffeine in compound acetylsalicylic acid tablets by multiple regression spectrophotometry |
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| Abstract:OBJECTIVE To determine phenacetin and caffeine in compound acetylsalicylic acid tablets. METHODS Multiple regression spectrophotometry was adopted as follow:The sample is dissolved in ethanol,add solution of 02mol/L NaOH to hydrolysis acetylsalicylic acid,the components are determined in phosphate salt buffet (pH 6.5). RESULTS The average recoveries for phenacetin and caffeine were 99.8% and 99.9%,with RSD 0.72% and 0.52%,respectively. CONCLUSION Accuracy of the method was compared with official quantitative analysis and no significant difference was found. |
| keywords:multiple regression spectrophotometry compound acetylsalicylic acid tablets phenacetin caffeine determination |
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