| 酮基布洛芬贴片的制备及体外渗透性研究 |
| 投稿时间：1998-07-21 点此下载全文 |
| 引用本文：胡晋红,张万国,郑晓梅.酮基布洛芬贴片的制备及体外渗透性研究[J].药学实践杂志,1999,(1):27~28 |
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| 中文摘要:目的 制备酮基布洛芬凝胶贴片,并考察体外经皮渗透性。方法 以聚乙烯醇(PVA)和甘油为载体,以尿素为促进剂。结果 药物经皮渗透符合零级动力学过程,贴片中尿素含量超过10%时,有显着的透皮促进作用。结论 贴片制剂稳定,符合临床用药要求。 |
| 中文关键词:酮基布洛芬 聚乙烯醇 体外释药 透皮贴片 |
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| Preparation and in vitro evaluation of ketoprofen gel for transdermal drug delivery |
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| Abstract:OBJECTIVE To study the prepartion of ketoprofen gel and its in vitro release. METHODS PVA and glycerin was used as carriers. RESULTS KFP was delivered at zero order.The higher the drug content,the faster the delivery speed.5% urea had no effect on KFP transdermal delivery.At a content of more than 10%,urea could significantly accelerate KFP transdermal delivery. CONCLUSION Gel was stable and accorded the clinical demands. |
| keywords:ketoprofen polyvinyl alcohol in vitro release transdermal patch the clinical demands. |
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