| 尼莫地平软胶囊人体相对生物利用度研究 |
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| 引用本文：蔡长春,李景苏,杨尊湘,谢晓婵.尼莫地平软胶囊人体相对生物利用度研究[J].药学实践杂志,1997,(5):288~290 |
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| 中文摘要:本文用高效液相色谱法测定了8名健康志愿者单剂量口服尼莫地平软胶囊剂60mg和等剂量进口尼莫地平薄膜包衣片剂的生物利用度,结果表明两剂型的Tmax、Cmax、AUC均无显著差异(P>0.05),两剂型具生物等效性。 |
| 中文关键词:尼莫地平软胶囊 生物利用度 高效液湘色谱法 |
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| Studies on bioavailability of nimodipine soft capsules in healthy volunteer |
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| Abstract:A single oral dose of tablets or soft capsules of 60mg nimodipine was given to 8 healthy volunteers in a randomized crossover study.plasma levels were determined with HPLC method.The plasma concentration-time curve fitted 1-compartment open model,and 2 dose comparative Tmax,Cmax,AUC were not significantly different from that of the tablets(P>0.05).Although the sofe capsules could reach peak level faster,the bioavailability with same biological effect. |
| keywords:nimodipine soft capsules bioavailability HPLC method |
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