| 中文摘要:本文利用FPIA法测定了家兔丁胺卡那霉素单用及与SMZ-TMP或TMP合用时的药代动力学变化。结果测得(Ⅰ)单用时Ke=0.0108±0.0013min-1,T1/2=65.89±7.30min,AUC=60.2908±278.03min·μg/ml,Tpeak=29.94±11.06min,CL/f(s)=0.0006790±0.0001461/kg·min;(Ⅱ)与SMZ-TMP合用时Ke=0.0094±0.0011min-1,T1/2=75.05±0.67min,AUC=7756.37±1100.73min·μg/ml,Tpeak=18.31±7.77min,CL/f(s)=0.00054±0.0000861/kg·min;(Ⅲ)与TMP合用时Ke=0.0092±0.0006min-1,T(1/2)=74.23±5.20min,AUC=7343.10±999.91min·μg/ml,Tpegk=17.67±5.33min,CL/f(s)=0.00054±0.0000861/kg·min,其中,(Ⅰ)与(Ⅱ),(Ⅰ)与(Ⅲ)有显著性差异(P<0.05),但(Ⅱ)与(Ⅲ)无显著性差异(P>0.05)。另外,合用SMZ-TMP或TMP前后,T1/2(ka), Ka, Cmax, Vd/f(c)均没有显著性差异(P>0.05)。 |
