| 前列腺素E1栓剂治疗肺心病呼衰并肺动脉高压的近期疗效观察 |
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| 引用本文：陈巍,唐存存,金蕊贤,杨延利,蔡定国,程海燕,叶航生.前列腺素E1栓剂治疗肺心病呼衰并肺动脉高压的近期疗效观察[J].药学实践杂志,1996,(1):12~14 |
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| 中文摘要:观察26例肺心病呼衰并肺动脉高压患者应用前列腺素E1(PGE1)栓剂治疗前后血浆TXB2、6K-PGE1a及PAmP的变化。结果发现,血浆TXB2及PAmP治疗后均明显低于治疗前(P<0.01及P<0.001),血浆6-K-PGF1a治疗后则明显高于治疗前(P<0.001).提示PGE1栓剂治疗肺心病呼衰患者肺动脉高压的近期疗效是显着的,可能通过调节TXB2──6-K-PGF1a平衡失调,间接发挥扩张血管的作用,并克服了静脉应用PGE1及其他扩血管药物引起的体循环低血压等副作用。 |
| 中文关键词:前列腺素E1栓剂 肺动脉平均压 血栓素B2 6－酮－前列腺素F1α |
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| Effects of prostaglandin E1 suppository on pulmonary hypertension of patients with cor pulmonale complicated with respiratory failure during treatment |
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| Abstract:Twenty cases of protaglandin E1 suppository treatment against cor pulmonale complicated with respiratory failure and pulmonary hypertension were investigated. The reults show that TXB2 and PAmP were remarkably lower than those before the treatment(P<0.001), and 6-keto-PGF1a was significantly highter(P<0.001). Suggesting that prostaglandin E1 suppository is satisfactory during the treatment. |
| keywords:Prostaglandin E1 pulmonary hypertension TXB2 6-keto-PGF1α |
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