| 二乙基二硫代氨基甲酸钠对沙土鼠脑缺血再灌注损伤的保护作用 |
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| 引用本文：李飒,李万亥,陶学斌,陈东明,陈洁.二乙基二硫代氨基甲酸钠对沙土鼠脑缺血再灌注损伤的保护作用[J].药学实践杂志,1995,(3):136~139 |
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| 中文摘要:蒙古沙土鼠脑缺血60min后,脑组织能量物质ATP、ADP明显下降,且有可检测的次黄嘌呤(HX)产生;氧自由基含量有上升趋势。再灌注5min时,氧自由基(OFR)含量显着增加;灌注30min时,ATP、ADP有所回升,HX降至无法检测,OFR降至缺血组水平。脑缺血180min再灌注60min,神经细胞坏死,组织肿胀,动物死亡率达85%.缺血前15miniv DTC 50mg·kg-1,ATP恢复较再灌注组更明显;神经细胞及组织肿胀均有明显改善;动物死亡率降至50%.提示黄嘌呤氧化酶途径可能是脑内氧自由基产生的重要途径,而DTC对脑缺血再灌注损伤具有保护作用。 |
| 中文关键词:二乙基二硫代氨基甲酸 三磷酸腺苷 氧自由基 沙土鼠 脑缺血再灌注损伤 |
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| Protective effects of sodium diethyldithiocarbamate on ischemia-reperfusion-induced brain injury in Mongolian gerbil |
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| Abstract:Brain injury in Mongolian gerbil(Meriones unguiculatus) was induced by occluding bilateral common carotid arteries followed by reperfusion. Levels of ATP, ADP and HX in gerbil brain measured by HPLC method were decreased and increased significantly respectively after 60 min cerebral ischemia. The level of oxygen free radicals(OFR) measured by electron spin resonance(ESR)were increased significantly only at 5-min reperfusion. DTC, iv 50 mg·kg-115 min before occlusion, increased level of ATP and ADP in brain,reduced edema of neuron and tissue of brain and decreased the level of OFR in 5-min reperfusion group and the mortality of gerbil to 50% as dexame thasone did in the reperfusion group. The results suggested that DTC had protective effects on ischemia-reperfusion induced gerbil brain injury. The OFR in gerbil brain may be formated mainly by the route of xanthine oxidase. |
| keywords:diethyldithiocarbamate adenosine triphosphate oxygen free radicals Mongolian gerbil ischemia-reperfusion-induced brain injury |
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