| 粉防己碱对大鼠离体主动脉条45Ca内流的影响 |
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| 引用本文：唐仲进,王秀英,陈红,关英,朱铨英,苏定冯.粉防己碱对大鼠离体主动脉条45Ca内流的影响[J].药学实践杂志,1995,(2):72~75 |
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| 中文摘要:本文研究了粉防己碱(Tetradrine,Tet)对大鼠离体胸主动脉条45Ca内流的影响。结果表明,粉防己碱(3×10-5mol·L-1)与维拉帕米(Verapamil,浓度为1×10-5mol·L-1)相似,可以抑制高K+激发的主动脉条45Ca的内流量,但不能阻断由苯肾上腺素(Phenylephrine,浓度为1×10-5mol·L-1)激发的45Ca内流量。结果提示,粉防己碱可能是选择性地阻断电压操纵的钙通道而抑制45Ca内流。 |
| 中文关键词:粉防己碱 高K+ 苯肾上腺素 45Ca 电压操纵的钙通道 |
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| Effect of tetrandrine on 45Ca influx in rat aorta in vitro |
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| Abstract:The effects of tetrandrine on calcium influx were studied in rat aorta in vitro.It was found that tetrandrine, similar to verapamil, significantly inhibited high-K+-induced 45Ca influx. But tetrandrine could not inhibit 45Ca influx evoked by phenylephrine, These results suggest that tetrandrine has a specific inhibitary effect on smooth muscle 45Ca influx by inhibiting voltage-operated calcium channel. |
| keywords:tetrandrine high-K+ phenylephrine 45Ca calcium channel |
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