| 醛脱氢酶2改善铁死亡相关疾病预后的研究进展 |
| 投稿时间：2024-11-30 修订日期：2025-03-05 点此下载全文 |
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| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要:氧化应激是铁死亡发展和进展的重要病理生理途径。病理条件下，大量的活性氧（ROS）的产生超过了抗氧化防御系统的缓冲能力，导致细胞在氧化应激状态下脂质过氧化，进而出现细胞铁死亡。细胞脂质过氧化还会生成毒性醛，从而与重要生物大分子作用，破环细胞正常功能。目前研究发现醛脱氢酶2（ALDH2）能消除这些醛类物质，调控毒性醛—ROS—氧化应激—脂质过氧化这个循环，从而起到改善与铁死亡相关的疾病预后效果。本文对铁死亡和ALDH2进行了简要介绍，并总结了目前ALDH2改善铁死亡相关疾病的研究工作，可为后续与铁死亡相关的疾病治疗研究拓展新的方向。 |
| 中文关键词:氧化应激 活性氧 铁死亡 醛脱氢酶2 毒性醛 |
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| Advances in Research on Aldehyde Dehydrogenase 2 in Improving the Prognosis of Ferroptosis-Related Diseases |
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| Abstract:Oxidative stress is an important pathophysiological pathway for the development and progression of ferroptosis. Under pathological conditions, the production of a large amount of reactive oxygen species (ROS) exceeds the buffering capacity of the antioxidant defense system, resulting in lipid peroxidation and cell ferroptosis in the state of oxidative stress. Cellular lipid peroxidation can generate toxic aldehydes, which interact with important biological macromolecules and break the normal function of cells. At present, it has been found that aldehyde dehydrogenase 2 (ALDH2) can eliminate these aldehydes and regulate the cycle of toxic aldehydes-ROS-oxidative stress-lipid peroxidation, thereby improving the prognosis of diseases associated with iron death. This article briefly introduces ferroptosis and ALDH2, and summarizes the current researches on ALDH2 to improve diseases associated with iron death, which can open up new directions for the subsequent research on the treatment of diseases associated with iron death. |
| keywords:: Oxidative stress Reactive oxygen species Ferroptosis Aldehyde dehydrogenase 2 Toxic aldehydes |
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