| 九味永安颗粒联合西替利嗪治疗湿疹湿热蕴肤证的临床疗效观察 |
| 投稿时间：2024-07-22 修订日期：2025-03-07 点此下载全文 |
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| 基金项目:海军军医大学第一附属医院“234学科攀峰计划”临床学科创新项目(No.2020YXK027)；上海市2023年度“科技创新行动计划”医学创新研究专项项目（No.23Y31920303）； |
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| 中文摘要:目的 观察九味永安颗粒联合西替利嗪治疗湿疹湿热蕴肤证的临床疗效。方法选取2021年12月至2023年3月在海军军医大学第一附属医院中医外科接受治疗108例湿热蕴肤证湿疹患者，采用随机数字表法分为观察组和对照组，各54例。两组患者基础治疗均予口服盐酸西替利嗪片, 观察组予九味永安颗粒，对照组予九味永安颗粒安慰剂。观察比较两组治疗前后临床疗效，包括中医证候积分、湿疹面积及严重度指数（EASI）、瘙痒程度评分（VAS），以及不良反应等。结果 治疗后观察组总有效率（88.9%）高于对照组（77.8%），差异有统计学意义（P＜0.05）；治疗后，观察组的中医证候积分、EASI以及VAS均较对照组显著降低（P＜0.05），差异有统计学意义；两组不良反应总发生率无明显差异（P＞0.05）。结论 观察组九味永安颗粒联合西替利嗪片治疗湿疹湿热蕴肤证较对照组临床疗效显著，不仅可以有效缓解患者病情、缩减皮损面积，还能改善瘙痒症状，安全有效，具有临床推广价值。 |
| 中文关键词:湿疹 湿热蕴肤证 九味永安颗粒 湿疹面积及严重度指数 |
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| Clinical observation on Jiu-Wei-Yong-An granule combined with cetirizine in the treatment of eczema with damp-heat accumulation of skin syndrome |
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| Abstract:Objective To observe the clinical effect of Jiu-Wei-Yong-An Granule combined with cetirizine in the treatment of damp-heat accumulation syndrome of eczema. Methods 108 eczema patients with syndrome of damp-heat accumulated in the skin, treated in the Department of Traditional Chinese Surgery in the First Affiliated Hospital of Naval Medical University from December 2021 to March 2023, were selected. They were randomly divided into an observation group and a control group, 54 cases each. Both groups took cetirizine tablets orally for basic treatment. The observation group was given Jiu-Wei-Yong-An Granules, and the control group was given placebos of the same. The clinical efficacy before and after treatment in the two groups was observed and compared, including TCM syndrome scores, Eczema Area and Severity Index (EASI), Visual Analogue Scale (VAS), and adverse reactions. Results After treatment, the total effective rate of the observation group (88.9%) was higher than that of the control group (77.8%), and the difference was statistically significant (P < 0.05). After treatment, the TCM syndrome score, EASI and VAS in the observation group were significantly lower than those in the control group (P < 0.05), and the difference was statistically significant. There was no significant difference in the total rate of adverse reactions between the two groups (P > 0.05). Conclusion The combination of Jiu-Wei-Yong-An Granules and cetirizine tablets in the treatment of damp-heat eczema showed significantly better clinical outcomes in the observation group compared to the control. It effectively improved patient conditions, reduced skin lesion areas, and alleviated itching, with both safety and efficacy that merit clinical promotion. |
| keywords:eczema damp-heat evidence Jiu-Wei-Yong-An Granules Eczema area and severity index |
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