| 耐碳青霉烯类肠杆菌耐药机制的研究进展 |
| 投稿时间：2024-05-06 修订日期：2024-09-10 点此下载全文 |
| 引用本文：钱淑雨,李铁军.耐碳青霉烯类肠杆菌耐药机制的研究进展[J].药学实践杂志,2024,42(10):419~425 |
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| 基金项目:上海市浦东新区卫生系统学科建设项目：新兴、交叉学科（精准临床药学，PWXx2020-03） |
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| 中文摘要:耐碳青霉烯类肠杆菌（CRE）是全球范围内日益严重的人类健康威胁。CRE通常携带多种耐药基因，限制了治疗药物选择，需要更长的治疗时间，治疗费用更高且治疗风险更大。该综述概述了CRE的流行病学、耐药机制、耐药现状以及最新治疗药物的介绍。为临床合理使用抗菌药物，耐药菌感染的防控和治疗提供依据。 |
| 中文关键词:耐碳青霉烯类肠杆菌 耐药机制 抗感染治疗 |
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| Research progress on resistance mechanisms of carbapenem-resistant Enterobacteriaceae |
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| Abstract:Carbapenem-resistant Enterobacteriaceae （CRE） is an increasingly serious threat to human health worldwide. CRE usually carries multiple drug resistance genes, which limit the selection of therapeutic drugs, prolong treatment time, require higher treatment costs and greater treatment risks. The epidemiology, resistance mechanisms, current resistance status of CRE and the latest therapeutic drugs for CRE were summarized in this papoer, which provide a basis for the rational use of antibiotics in clinical prevention and treatment of drug-resistant bacterial infections. |
| keywords:carbapenem-resistant Enterobacteriaceae mechanisms of drug resistance anti-infective treatment |
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