| 秀丽隐杆线虫在抗感染研究中的应用 |
| 投稿时间：2013-07-04 修订日期：2013-11-17 点此下载全文 |
| 引用本文：胡淦海,李德东,赵兰雪,王彦,姜远英.秀丽隐杆线虫在抗感染研究中的应用[J].药学实践杂志,2014,32(1):5~8 |
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| 基金项目:国家自然科学基金(81273558,81072678,90913008);国家重点基础研究发展计划(2013CB531602);国家科技部科技重大专项(2011ZX09102-002-01);上海市科技重点项目(10431902200). |
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| 中文摘要:目的 介绍秀丽隐杆线虫(Caenorhabditis elegans)作为模式生物宿主在抗感染研究中的应用,为秀丽隐杆线虫在抗感染研究领域的进一步应用提供参考。方法 参阅近年来国内、外相关文献,对其进行分析、整合及归纳。结果 发现秀丽隐杆线虫具有生长周期短、成本低等特点,被广泛用于病原微生物致病机制的研究以及抗感染药物的研发。结论 秀丽隐杆线虫在病原微生物致病机制研究和抗感染药物研发中有广阔的应用前景。 |
| 中文关键词:秀丽隐杆线虫 病原微生物 致病机制 抗感染药物 |
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| Application of Caenorhabditis elegans in anti-infective research |
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| Abstract:Objective To update the application of Caenorhabditis elegans as a model host of infection in anti-infection research field, and provide references for the further application of C. elegans in the research field. Methods The related literatures at home and abroad in recent years were analyzed, integrated and concluded. Results C. elegans had been widely used to study pathogenesis of microorganisms and to screen anti-infective agents, since the nemades had short life cycle and cost low. Conclusion C. elegans would be promising to be further more widely used to study pathogenesis and anti-infective agents. |
| keywords:Caenorhabditis elegans pathogenic microorganisms pathogenesis anti-infective agents |
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