| 4-苯基-5-乙氧羰基-6-甲基-3,4-二氢嘧啶-2(1H)-酮的绿色合成研究 |
| 投稿时间：2010-05-25 修订日期：2010-06-10 点此下载全文 |
| 引用本文：郭尧,陈颖,于宗民,袁文琳,王小燕,何邦平,孙青龑.4-苯基-5-乙氧羰基-6-甲基-3,4-二氢嘧啶-2(1H)-酮的绿色合成研究[J].药学实践杂志,2011,29(1):29~30,77 |
| 摘要点击次数: 1542 |
| 全文下载次数: 103 |
|
| 基金项目:第二军医大学教学研究重点项日(JYB2008004),第二军医大学大学生创新重点项目(ZD2009001) . |
|
| 中文摘要:目的 探索操作简便,环境友好的4-苯基-5-乙氧羰基-6-甲基-3,4-二氢嘧啶-2(1H)-酮的合成方法。 方法 以苯甲醛、乙酰乙酸乙酯和尿素作为起始原料,在无溶剂和微波加热条件下,选择1-丁基-3-甲基咪唑氯盐和1-丁基-3-甲基咪唑-L-乳酸盐两种不同的离子液体分别催化Biginelli反应制备4-苯基-5-乙氧羰基-6-甲基-3,4-二氢嘧啶-2(1H)-酮,并比较两种离子液体的催化效果。 结果 两种离子液体在微波、无溶剂条件下均可催化Biginelli反应制得目标化合物,其中1-丁基-3-甲基咪唑-L-乳酸盐作为催化剂目标化合物收率较高。 结论 以离子液体-丁基-3-甲基咪唑-L-乳酸盐作为催化剂,经微波、无溶剂Biginelli反应制备4-苯基-5-乙氧羰基-6-甲基-3,4-二氢嘧啶-2(1H)-酮,是一种易于操作的绿色合成方法。 |
| 中文关键词:4-苯基-5-乙氧羰基-6-甲基-3,4-二氢嘧啶-2(1H)-酮 Biginelli反应 绿色合成 |
| |
| Environmentally synthesis of 4-phenyl-5-ethoxycarbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one |
|
|
| Abstract:Objective To explore an easily-controled, environmentally benign synthetic method of 4-phenyl-5-ethoxycarbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one. Methods 4-phenyl-5-ethoxy-carbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one was synthesized from benzaldehyde, ethyl acetoacetate and urea through the Biginelli reaction catalysed by two different ionic liquid (1-butyl-3-methylimidazolium chloride and 1-butyl-3-methylimidazolium (L)-lactate) under microwave irradiation without a solvent respectively. Results Both ionic liquid catalysts could catalyse Biginelli reaction to get the title compound under microwave irradiation without a solvent. Compared with 1-butyl-3-methylimidazolium chloride, 1-butyl-3-methylimidazolium (L)-lactate was a better catalyst to get a more satisfied yield of the title compound. Conclusion Microwave accelerated solvent-free Biginelli reaction using green ionic liquid of 1-butyl-3-methylimidazolium (L)-lactate as catalyst was a convenient and environmentally benign synthetic method of 4-phenyl-5-ethoxycarbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one. |
| keywords:4-phenyl-5-ethoxycarbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one Biginelli reaction environmentally benign synthesis |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
