| 阿德福韦酯自乳化制剂大鼠体内药动学的初步研究 |
| 投稿时间：2008-09-22 点此下载全文 |
| 引用本文：王金锐,陈建明,王建超.阿德福韦酯自乳化制剂大鼠体内药动学的初步研究[J].药学实践杂志,2009,27(4):276~278 |
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| 中文摘要:目的:研究阿德福韦酯自乳化制剂在大鼠体内的药动学过程。方法:以随机分组组间对照实验设计方法,通过高效液相色谱法测定6只SD大鼠(两组)体内单剂量灌胃服用阿德福韦酯自乳化制剂和片剂100mg/kg后不同时间点的血药浓度,并计算其药动学参数。结果:自乳化制剂组大鼠的Cmax为2.509 4μg/mL,AUC为277.291 1μg.m in/mL);片剂组大鼠的Cmax为1.725 8μg/mL,AUC为215.919 6μg.m in/mL)。结论:阿德福韦酯自乳化制剂的口服生物利用度优于片剂。 |
| 中文关键词:阿德福韦酯 自乳化制剂 药动学 高效液相色谱 |
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| Pharmacokinetics study of self-emulsifying drug delivery systems of adefovir dipivoxil in rat |
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| Abstract:Objective: To study the pharmacokinetics of self-emulsifying drug delivery systems of adefovir dipivoxil in rats.Methods: Six SD rats were randomly divided into two groups for oral administration of the self-emulsifying adefovir dipivoxil and adefovir dipivoxil tablets at a single dose of 100 mg/kg.HPLC method was applied to determine the plasma concentration of these two groups.The calculations of pharmacokinetic parameters were performed with 3P87 program.Results:For the self-emulsifying adefovir dipivoxil,Cmax and AUC were 2.509 4 μg/mL and 277.291 1 μg·min/mL,respectively;while for adefovir sipivoxil tablet,Cmax and AUC were 1.725 8 μg/mL and 215.919 6 μg·min/mL,respectively.Conclusions:The oral bioavailability of the self-emulsifying adefovir dipivoxil was better than tadefovir dipivoxil tablet. |
| keywords:adefovir dipivoxil self-emulsifying drug delivery systems pharmacokinetics HPLC |
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