| 血清丙戊酸、卡马西平血清样品的稳定性考察 |
| 投稿时间：2007-03-06 点此下载全文 |
| 引用本文：周亮,王明媚,马建丽.血清丙戊酸、卡马西平血清样品的稳定性考察[J].药学实践杂志,2008,(2):145~146,153 |
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| 中文摘要:目的:考察丙戊酸、卡马西平血清样品保存条件对血清药物浓度的影响。方法:取癫痫患者血清样品,在取血当天、冰箱冷藏(5℃±1℃)保存7 d、常温(23℃±2℃)保存7 d与14 d后,用荧光偏振免疫法测定血清丙戊酸、卡马西平浓度并进行比较,考察其稳定性。结果:室温保存7 d、14 d或冷藏保存7 d的血样测定结果与取血当天测定结果比较无统计学差异。结论:丙戊酸、卡马西平血清样品在室温下可稳定保存14d。 |
| 中文关键词:卡马西平 血药浓度 稳定性 |
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| Study on stability of valproic acid and carbamazepine concentrations in serum samples |
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| Abstract:Objective: To investigate the effects on serum drug concentrations of valproic acid and carbamazepine with different storage requirements of serum sample.Methods:Methods The serum samples from epileptic patients were stored at normal temperature(23 ℃±2 ℃)for 7 days and 14 days or in refrigerator(5 ℃±1 ℃) for 7 days.Then these samples were determined by FPIA and the results were compared with the new ones.Results:Compared with the new samples,the samples which were stored for 7 or 14 days were no significant differences.Conclusion:Serum samples of valproic acid and carbamazepine can be stored stably at normal temperature for 14 days. |
| keywords:valproic acid carbamazepine serum drug concentration stability |
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