| 高效液相色谱法同时测定肤康涂膜剂中水杨酸和酮康唑的含量 |
| 投稿时间：2003-05-23 点此下载全文 |
| 引用本文：盛国荣,谢勇.高效液相色谱法同时测定肤康涂膜剂中水杨酸和酮康唑的含量[J].药学实践杂志,2004,(1):5~7 |
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| 中文摘要:目的 建立一种高效液相色谱法测定肤康涂膜剂中水杨酸和酮康唑的含量。方法 采用C18柱,乙腈-甲醇-2%醋酸铵(14:43:43)为流动相,检测波长为235nm,柱温 30℃。结果 水杨酸线性范围 0.5～2.5mg/mL(r=0.9999),平均回收率为99.8%,RSD=0.64%(n=9),酮康唑线性范围0.5～25mg/mL(r=0.9999),平均回收率为 100.6%,RSD=0.86%(n=9)。结论 该法简便,灵敏,准确。 |
| 中文关键词:HPLC 水杨酸 酮康唑 |
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| Simultantous determination of salicylic acid and ketoconzole in the Fukang balm by HPLC |
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| Abstract:Objective To establish a HPLC method for determine of salicylic acid and ketoconazole in the Fukang balm.Methods C18 column was adopted as stationary phase, solvent mixiure composed of acetonitrile-methanol-2% ammonium acetate (14:43:43) was used as mobile phase, the detection wavelength was 235nm, the temperature of column was 30℃. Result Salicylic acid had a good linearity (r=0.9999) in the range of 0.5～2.5mg/mL, the mean recovery was 99.8%, and RSD=0.64%(n=9). Ketoconazole had a good linearity (r=0.9999) in the range of 0.5～2.5mg/mL, the mean recovery was 100.6%, and RSD=0.86%(n=9). Conclusion The above method is simple, sensitive and accurate. |
| keywords:HPLC Salicylic acid kefoconazole |
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