炎症小体介导的细胞焦亡在非酒精性脂肪肝病中的作用及机制
投稿时间:2019-02-22  修订日期:2019-07-18  点此下载全文
引用本文:张文杰,孙迪阳,王培.炎症小体介导的细胞焦亡在非酒精性脂肪肝病中的作用及机制[J].药学实践杂志,2020,38(1):9~13,41
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作者单位E-mail
张文杰 海军军医大学药学院药理学教研室, 上海 200433  
孙迪阳 海军军医大学药学院药理学教研室, 上海 200433  
王培 海军军医大学药学院药理学教研室, 上海 200433 pwang@smmu.edu.cn 
中文摘要:非酒精性脂肪肝病包含单纯性脂肪肝、非酒精性脂肪肝炎和肝硬化等一系列病变,是造成肝硬化、肝细胞癌症的主要因素和肝脏器官移植的重要诱因。非酒精性脂肪肝的发病机制尚不明确,除了加强运动、改善饮食习惯外,目前尚无公认有效的药物治疗方式。细胞焦亡是一种新发现的程序性细胞死亡方式,依赖于天冬氨酸特异性半胱氨酸蛋白酶1(caspase-1)或caspase-11等介导的炎性小体的激活。细胞焦亡过程中常伴有炎症反应的发生,而炎症小体则是细胞产生焦亡和炎症反应所必需的多聚体蛋白复合物,其主要功能是活化caspase-1,从而间接调控炎症因子白介素1(IL-1)和IL-18的表达和分泌。最近的研究表明,细胞焦亡和炎症小体在非酒精性脂肪肝病的发生发展中起重要作用。针对该领域的最新研究进行综述,以期为非酒精性脂肪肝的防治提供新的科学认识和信息。
中文关键词:炎症小体  细胞焦亡  非酒精性脂肪肝  药物靶点  caspase-1
 
The role and mechanism of inflammasome-associated pyroptosis in nonalcoholic fatty liver disease
Abstract:Non-alcoholic fatty liver disease (NAFLD), which is a series of diseases including simple fatty liver, nonalcoholic steatohepatitis and cirrhosis, is one of the main causes of liver cirrhosis, carcinoma and liver transplantation. The mechanism of NAFLD is not fully understood. Besides the physical exercise and diet intervention, there is no recognized effective drug therapy for NAFLD. Pyroptosis is a newly discovered type of programmed cell death, which is associated with activation of caspase-1, or caspase-2 mediated inflammasome activation. The main function of inflammasome is to activate caspase-1, which indirectly regulates the expression and secretion of inflammatory factors interleukin-1 and interleukin-18. Recent studies have shown that inflammasome-associated pyroptosis plays a key role in NAFLD. This review will discuss the latest researches in this field to provide new scientific knowledge for prevention and treatment of NAFLD.
keywords:inflammasome  pyroptosis  non-alcoholic fatty liver disease  drug target  caspase-1
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