| 百令胶囊用于肾移植术后患者的临床疗效分析 |
| 投稿时间：2022-06-28 修订日期：2023-09-28 点此下载全文 |
| 引用本文：庞素秋.百令胶囊用于肾移植术后患者的临床疗效分析[J].药学实践杂志,2024,42(2):82~85 |
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| 基金项目:福建省泉州市科技项目(2018N136S) |
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| 中文摘要:目的 回顾性分析联勤保障部队第910医院（本院）60例肾移植术后患者服用百令胶囊的临床效果，探讨百令胶囊对肾移植术后患者的肾功能及其他机体系统的影响。方法 从医院HIS系统抽调2018?2020年于本院就诊的60例同种异体肾移植术后患者用药资料，依照不同的免疫抑制剂给药方案分成2组，分别为对照组35例：霉酚酸酯（MMF）联合环孢素A（CsA）或他克莫司（FK506）；治疗组25例：MMF联合CsA或FK506同时联合百令胶囊。术后检测肝、肾功能，血、尿常规及尿酸等；随访并分别记录1、4、12、24、48周免疫抑制剂CsA和FK506的使用量。结果 治疗组尿中红细胞数量、白细胞数量、血谷草转氨酶和谷丙转氨酶、血清尿酸、总胆红素、直接胆红素显著少于对照组，而血清总蛋白、白蛋白显著高于对照组；治疗组血红细胞、白细胞数量在肾移植术后12~48周显著高于对照组，淋巴细胞在肾移植术后24~48周显著高于对照组。治疗组CsA或FK506的用量在术后48周之后显著低于对照组。结论 百令胶囊能有效减轻肾移植术后患者的常见并发症状，并具有减少免疫抑制剂使用量等效果，可作为一种较理想的免疫调节剂用于肾移植术后患者的治疗。 |
| 中文关键词:百令胶囊 他克莫司 环孢素A 肾移植 免疫调节 |
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| Clinical effect of Bailing capsule on patients after renal transplantation |
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| Abstract:Objective To study the effect of Bailing capsule on renal function and other organ systems in 60 patients after renal transplantation in No. 910 Hospital of Joint Logistics Support Force. Methods 60 patients with renal allograft in 2018?2020 were divided into 2 groups according to different immunosuppressive regimens. In the control group, 35 cases were treated with MMF + CsA or FK506; in the treatment group, 25 cases were treated with MMF + CsA or FK506 + Bailing capsule. Blood and urine routine, liver and renal function and uric acid were measured after operation. The dosage of immunosuppressive drugs was recorded in stages at 48 weeks.Results The urinary red and white blood cell counts, blood aspartate transaminase and alanine transaminase, serum uric acid, total bilirubin and direct bilirubin in the treatment group were significantly less than those in the control group, while the serum total protein and albumin were significantly higher than those in the control group. The number of red blood cells and white blood cells in the treatment group was significantly higher than that in the control group at 12-48 weeks after kidney transplantation, and that in the lymphocyte group was significantly higher than that in the control group at 24-48 weeks after kidney transplantation. The dosage of CsA and FK506 in the treatment group was significantly lower than that in the control group after 48 weeks. Conclusion Bailing capsule could protect liver and kidney, stimulate hematopoiesis, improve hypoalbuminemia and reduce the dosage of immunosuppressant, which could be an ideal immunomodulator. |
| keywords:Bailing capsule tacrolimus cyclosporine A renal transplantation immunoregulation |
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