| 盐酸二甲双胍片对多囊卵巢综合征治疗临床疗效、优势卵泡个数的影响 |
| 投稿时间：2022-08-19 修订日期：2023-11-30 点此下载全文 |
| 引用本文：李慧,唐淮云,关慧娟,张帅.盐酸二甲双胍片对多囊卵巢综合征治疗临床疗效、优势卵泡个数的影响[J].药学实践杂志,2023,41(12):763~766 |
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| 中文摘要:目的 探究盐酸二甲双胍片对多囊卵巢综合征治疗临床疗效、优势卵泡个数的影响。方法 选取2019年1月至2021年3月在江苏省连云港妇幼保健院诊治且确诊为多囊卵巢综合征的150例患者作为研究主体，采用随机数字表法将其分为观察组和对照组，每组各75例，对照组采用来曲唑+尿促性素治疗，观察组采用来曲唑+尿促性素+盐酸二甲双胍片治疗。对比两组的临床疗效、子宫内膜厚度、优质卵泡个数、性激素水平、血脂水平以及不良反应发生情况。 结果 ①观察组的治疗有效率为90.67%，显著高于对照组的78.67%（P<0.05）。②用药后观察组患者的子宫内膜厚度低于对照组，优质卵泡个数多于对照组（P<0.05）。③用药后观察组患者的黄体生长激素（LH）、促卵泡激素（FSH）和睾酮（T）水平低于对照组（P<0.05）。④用药后观察组患者的总胆固醇（TC）和甘油三酯（TG）低于对照组（P<0.05）。⑤观察组的不良反应发生率为8.00%，明显低于对照组的20.00%（P<0.05）。结论 来曲唑+尿促性素+盐酸二甲双胍片治疗对多囊卵巢综合征患者的性激素和血脂水平具有明显的改善作用，能够缓解患者的症状，改善其子宫状况，有较好的临床疗效。 |
| 中文关键词:盐酸二甲双胍片 来曲唑 尿促性素 多囊卵巢综合征 优势卵泡个数 |
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| Effects of metformin hydrochloride tablets on clinical efficacy and number of dominant follicles in polycystic ovary syndrome |
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| Abstract:Objective To explore the effect of metformin hydrochloride tablets on the clinical efficacy, number of dominant follicles and ovarian volume of polycystic ovary syndrome. Methods 150 patients diagnosed with polycystic ovary syndrome who were diagnosed and treated in our hospital from January 2019 to March 2021 were selected .The patients were divided into observation group and control group by random number table. The control group was treated with letrozole + gonadotropin, and the observation group was treated with letrozole + gonadotropin + hydrochloric acid + Metformin tablets. The clinical efficacy, endometrial thickness, number of high-quality follicles, sex hormone levels, blood lipid levels, and adverse reactions were compared between the two groups. Results ① The effective rate of treatment in the observation group was 90.67%, which was significantly higher than that in the control group, 78.67% (P<0.05). ② After treatment, the endometrial thickness of the observation group was lower than that of the control group, and the number of high-quality follicles was more than that of the control group(P<0.05). ③ After treatment, the levels of Luteinizing Hormone-LH, Follicle Stimulating Hormone-FSH and Testosterone (T) in the observation group were lower than those in the control group (P<0.05). ④ After treatment, the total cholesterol (TC) and triglyceride (TG) in the observation group were lower than those in the control group (P<0.05). ⑤ The incidence of adverse reactions in the observation group was 8.00%, which was significantly lower than 20.00% in the control group (P<0.05). Conclusion Letrozole + gonadotropin + metformin hydrochloride tablets could significantly improve the sex hormone and blood lipid levels in patients with polycystic ovary syndrome, relieve the symptoms of the patients, and improve their uterine condition, which had a good clinical effect. |
| keywords:metformin hydrochloride tablets letrozole urinary gonadotropin polycystic ovary syndrome number of dominant follicles |
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