| 治疗黑色素瘤的DC疫苗研究新进展 |
| 投稿时间：2022-11-15 修订日期：2023-05-08 点此下载全文 |
| 引用本文：张馨月,台宗光,朱全刚,陈中建,鲍蕾蕾.治疗黑色素瘤的DC疫苗研究新进展[J].药学实践杂志,2023,41(11):643~647 |
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| 作者 | 单位 | E-mail | | 张馨月 | 江西中医药大学, 江西 南昌, 330004
上海市皮肤病医院, 上海, 200443
海军军医大学第三附属医院药材科, 上海, 200438 | | | 台宗光 | 上海市皮肤病医院, 上海, 200443 | | | 朱全刚 | 上海市皮肤病医院, 上海, 200443 | | | 陈中建 | 上海市皮肤病医院, 上海, 200443 | | | 鲍蕾蕾 | 江西中医药大学, 江西 南昌, 330004
海军军医大学第三附属医院药材科, 上海, 200438 | annabao212@126.com |
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| 基金项目:国家自然科学基金面上项目（82172706，82073385） |
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| 中文摘要:黑色素瘤是最具侵袭性的皮肤恶性肿瘤，易发生早期转移和治疗后复发。治疗性肿瘤疫苗是新兴的免疫疗法，具有毒性低以及可抑制肿瘤转移的特点。目前已有多个针对黑色素瘤治疗性疫苗的研究，其中黑色素瘤治疗性树突状细胞（DC）疫苗引起了广泛关注。虽然肿瘤治疗性DC疫苗在黑色素瘤中的疗效已被多项研究证实，但该类疫苗存在免疫效应不足、单独使用疗效不佳等问题，仍具有较大的改进空间。本文对黑色素瘤的治疗性DC疫苗的研究现状进行了综述，并对肿瘤治疗性DC肿瘤的研究重点及优化策略进行展望。 |
| 中文关键词:黑色素瘤 治疗性肿瘤疫苗 树突状细胞 免疫疗法 |
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| Research progress on therapeutic DC vaccine against melanoma |
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| Abstract:Melanoma is the most aggressive skin malignant tumor, which is prone to early metastasis and relapse after treatment. Therapeutic tumor vaccines are new immunotherapies, which have the advantages of low toxicity and inhibiting tumor metastasis. Melanoma has a high mutation load and a large number of specific antigens. Currently, various types of tumor vaccines have been developed for melanoma, especially those based on dendritic cells (DC). Although the efficacy of therapeutic DC vaccines in melanoma has been confirmed by a number of studies, thesevaccines still have problems such as insufficient immune effect and poor efficacy when used alone, and there is still a large room for improvement. In this paper, the current research status of therapeutic DC vaccines for melanoma was reviewed, and the research key points and optimization strategy of therapeutic DC tumor were prospected. |
| keywords:melanoma therapeutic tumor vaccine dendritic cell immunotherapy |
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