| 咪达唑仑联合丙泊酚麻醉对腹腔镜胆囊切除术后患者恢复的影响 |
| 投稿时间：2022-06-20 修订日期：2023-03-17 点此下载全文 |
| 引用本文：石庭伟,肖慧,刘茂莉,周洁,朱玉霖.咪达唑仑联合丙泊酚麻醉对腹腔镜胆囊切除术后患者恢复的影响[J].药学实践杂志,2023,41(10):638~642 |
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| 中文摘要:目的 探究咪达唑仑联合丙泊酚对腹腔镜胆囊切除术后患者恢复的影响。方法 选择2019年4月至2021年1月期间入院行腹腔镜胆囊切除术的患者162例，根据不同麻醉方式的将其分为对照组（实施咪达唑仑麻醉）和观察组（实施咪达唑仑联合丙泊酚麻醉），各81例。对比两组手术前后应激指标水平，术前（T0）、术后24 h（T1）及48 h（T2）的MoCA评分，T0、术后第1天（T3）、2天（T4）的术后相关恢复情况。结果 观察组患者的术后Cor、NE水平及睁眼、拔管、定向力恢复时间、不良反应发生率均低于对照组（P<0.05）；T1、T2时观察组的MMSE评分、T3、T4时的睡眠质量评分均高于对照组（P<0.05）。结论 咪达唑仑联合丙泊酚用于腹腔镜胆囊切除术安全性高，患者术后恢复良好。 |
| 中文关键词:咪达唑仑 丙泊酚 腹腔镜胆囊切除术 应激反应 认知功能 睡眠质量 |
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| Effects of midazolam combined with propofol on recovery of patients with laparoscopic cholecystectomy |
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| Abstract:Objective To explore the effect midazolam combination with propofol on postoperative recovery in patients undergoing laparoscopic cholecystectomy.Methods A total of 162 patients who were admitted to the hospital for laparoscopic cholecystectomy from April 2019 to January 2021 were selected. According to different anesthesia methods, they were divided into control group (midazolam anesthesia) and observation group (midazolam combined with propofol anesthesia), with 81 cases in each group. The stress index levels before and after operation, MoCA scores before operation (T0), 24 h after operation (T1) and 48 h after operation (T2), sleep quality at T0, the first day after operation (T3) and the second day after operation (T4), the perioperative recovery were compared between the two groups.Results The levels of Cor and NE, the recovery time of eyes opening, extubation, orientation, and the incidence of adverse reactions in the observation group were lower than those in the control group (P<0.05). Observation group MMSE score when T1, T2, T3, T4 sleep quality score were higher than control group (P<0.05). Conclusion Midazolam combined with propofol was safe and had good postoperative recovery in patients undergoing laparoscopic cholecystectomy. |
| keywords:Midazolam Propofol Laparoscopic cholecystectomy Stress response Cognitive function Sleep quality |
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