卡培他滨致手足综合征严重程度与血浆中炎症因子含量的分析
投稿时间:2021-08-28  修订日期:2022-04-20  点此下载全文
引用本文:刘艳平,王志鹏,崔莉莉,许封菁,张蒙伟,高守红.卡培他滨致手足综合征严重程度与血浆中炎症因子含量的分析[J].药学实践杂志,2023,41(10):634~637
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刘艳平 海军军医大学附属长征医院药学部, 上海 200003
宜春学院化学与生物工程学院, 江西 宜春 336000 
 
王志鹏 海军军医大学附属长征医院药学部, 上海 200003  
崔莉莉 海军军医大学附属长征医院药学部, 上海 200003
宜春学院化学与生物工程学院, 江西 宜春 336000 
 
许封菁 海军军医大学附属长征医院药学部, 上海 200003  
张蒙伟 海军军医大学附属长征医院药学部, 上海 200003
宜春学院化学与生物工程学院, 江西 宜春 336000 
 
高守红 海军军医大学附属长征医院药学部, 上海 200003 gaoshouhong@smmu.edu.cn 
中文摘要:目的 检测并分析服用卡培他滨后出现手足综合征的结直肠癌患者血浆中主要炎症因子(IL-1β、IL-6、IL-10、IL-12、IL-17、IL-23、TNF-α、IFN-γ、CPR和CCL-5)与手足综合征之间的相关性。方法 收集35例服用卡培他滨的结直肠癌患者血浆样本,根据手足综合征分级诊断标准对其轻重程度进行划分,用ELISA试剂盒检测血浆中各炎症因子的含量。结果 所有炎症因子的标准曲线呈线性(r>0.9900),并测定了不同结直肠癌患者血浆中炎症因子的含量,其中,TNF-α 含量水平变化较为明显,且具有参考价值。结论 不同的炎症因子在不同分级的手足综合征患者血浆中浓度存在一定差异,且TNF-α 炎症因子含量水平与其发生手足综合症的轻重程度密切相关。
中文关键词:结直肠癌  卡培他滨  手足综合征  炎症因子
 
Analysis of association between severity of capecitabine-induced hand-foot syndrome and inflammatory factors
Abstract:Objective To investigate the correlation between plasma inflammatory factors [IL-1β, IL-6, IL-10, IL-12, IL-17, IL-23, TNF-α, TGF-β, IFN-γ, C-reactive protein (CPR) CCL-5] and hand-foot syndrome in colorectal cancer patients after taking capecitabine. Methods 35 colorectal cancer patients treated with capecitabine were collected and the degree of severity was divided according to the hand-foot syndrome grading diagnostic criteria. The concentrations of inflammatory factors in plasma were determined by ELISA kits. Results The standard curve of all inflammatory cytokines were linear (r>0.9900), and plasma concentrations of inflammatory cytokines in patients with colorectal cancer were determined. The concentration of TNF-α changed obviously, which had reference value. Conclusion The concentrations of different inflammatory factors were different and the concentration of TNF-α was closely correlated with the severity of hand-foot syndrome.
keywords:colorectal cancer  capecitabine  hand-foot syndrome  inflammatory factors
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