临床药师参与吉瑞替尼致QTc间期延长的病例分析
投稿时间:2023-09-20  修订日期:2023-11-22  点此下载全文
引用本文:崔晓林,付晓菲,杜艳红,刘娟,朱茜,刘子祺.临床药师参与吉瑞替尼致QTc间期延长的病例分析[J].药学实践杂志,2024,42(6):263~266
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作者单位E-mail
崔晓林 中国人民解放军 63680部队医院, 江苏 无锡 214400  
付晓菲 火箭军特色医学中心, 北京 100088  
杜艳红 火箭军特色医学中心, 北京 100088  
刘娟 火箭军特色医学中心, 北京 100088  
朱茜 中国人民解放军 63680部队医院, 江苏 无锡 214400  
刘子祺 火箭军特色医学中心, 北京 100088 705368757@qq.com 
基金项目:军队后勤自主项目(zzcws23j1021)
中文摘要:目的 探讨临床药师在1例急性髓系白血病患者应用吉瑞替尼引起QTc间期延长的病例中的作用,为此类患者的药物治疗和监护提供参考。方法 临床药师及时发现1例急性髓系白血病患者心电图异常情况,通过分析患者基础疾病、诊疗过程、治疗用药及其潜在相互作用参与临床诊疗。结果 临床药师怀疑QTc间期延长很可能是吉瑞替尼引起的不良反应,建议立即停用该药,复查心电图。医师采纳此建议,及时停止可疑药品吉瑞替尼药物治疗,3 d后复查心电图,患者QTc数值恢复至正常范围内。结论 临床药师参与临床诊疗过程,可为患者提供更优质的药学服务。
中文关键词:吉瑞替尼  QTc间期延长  不良反应  临床药师
 
Participation of clinical pharmacists in QTc interval prolongation induced by gilteritinib
Abstract:Objective To explore the role of clinical pharmacists involved in the case of a patient with acute myeloid leukemia whose QTc interval prolongation was induced by gilteritinib, and to provide reference for drug treatment and monitoring of those patients. Methods The abnormal electrocardiogram (ECG) of a patient with acute myeloid leukemia was found in time by clinical pharmacists, who participated in clinical diagnosis and treatment by analyzing the patient’s underlying diseases, diagnosis and treatment process, therapeutic drugs and their potential interactions. Results Clinical pharmacists suspected that the prolonged QTc interval was likely to be an adverse reaction caused by gilteritinib, and recommended immediate discontinuation of the drug and re-examination of the electrocardiogram.The physician took the suggestion to stop the suspected drug therapy with gilteritinib promptly, and ECG was rechecked 3 d later, and the QTc value returned to the normal range. Conclusion Clinical pharmacists participating in clinical diagnosis and treatment could provide better pharmaceutical care for patients.
keywords:gilteritinib  QTc interval prolongation  adverse drug reaction  clinical pharmacists
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