| 抗菌肽Epinecidin-1的研究进展 |
| 投稿时间：2021-08-19 修订日期：2022-09-30 点此下载全文 |
| 引用本文：王吉荣,韩涵,邓莉.抗菌肽Epinecidin-1的研究进展[J].药学实践杂志,2023,41(7):400~402,427 |
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| 中文摘要:Epinecidin-1抗菌肽是从石斑鱼中提取的一种小分子活性多肽，是其先天免疫防御系统抵抗各种病原体的第一道防线。体内外研究证实，Epinecidin-1抗菌肽不仅表现出广谱的抗病原体活性（包括细菌、真菌、病毒和寄生虫等），还具有免疫调节、抗癌以及伤口愈合等药理活性。归纳近年Epinecidin-1抗菌肽的有关研究，对该抗菌肽的作用机制、药理活性、潜在局限性及应用前景进行综述，为下一步研究提供依据。 |
| 中文关键词:抗菌肽 Epinecidin-1 作用机制 |
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| Research progress on antibacterial peptides Epinecidin-1 |
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| Abstract:The antimicrobial peptide Epinecidin-1 is a kind of small molecule active peptides extracted from Epinephelus coioides，which serves as the first line of defense for innate immune defense system of Epinephelus coioides against various pathogens. In vitro and in vivo studies have confirmed that the antimicrobial peptide Epinecidin-1 not only exhibits broad-spectrum anti-pathogen activities (including bacteria, fungi, viruses, and parasites, etc.), but also has pharmacological activities such as immune regulation, anti-cancer and wound healing. In this paper, the relevant research on the antimicrobial peptide Epinecidin-1 in recent years were summarized, including its mechanism of action, pharmacological activities, potential limitations and application prospects , so as to provide information for further research. |
| keywords:antimicrobial peptides Epinecidin-1 mechanism |
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