| 光滑念珠菌耐药机制的研究进展 |
| 投稿时间：2022-02-21 修订日期：2022-07-11 点此下载全文 |
| 引用本文：徐怡澜,阎澜.光滑念珠菌耐药机制的研究进展[J].药学实践杂志,2023,41(7):393~395,432 |
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| 基金项目:国家自然科学基金资助项目（82173867）；上海市科技创新行动计划国际科技合作项目（21430713000）；上海市浦江人才计划（21PJD081）；上海市创新行动计划生物医药领域科技支撑项目（19431901300） |
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| 中文摘要:随着念珠菌病患者中感染光滑念珠菌的比例逐年增加，光滑念珠菌已成为除白念珠菌、热带念珠菌外较为常见的致病念珠菌之一。抗光滑念珠菌的药物种类有限，随之而来的耐药问题日益严重，为临床治疗带来困难。本文综述了光滑念珠菌对唑类、棘白菌素类及多烯类药物的耐药机制。 |
| 中文关键词:光滑念珠菌 唑类 棘白菌素类 多烯类 耐药性 |
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| Research progress on drug resistance mechanism of Candida glabrata |
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| Abstract:With the increasing proportion of Candida glabrata in patients with candidiasis, C. glabrata has become one of the most common pathogenic Candida in clinical practice. There are limited types of antifungal drugs, and the consequent problem of drug resistance is severely increasing, which brings difficulties to clinical treatment. The resistance mechanisms of C. glabrata to azoles, echinocandins and polyenes were reviewed in this paper. |
| keywords:Candida glabrata azole echinocandin polyene drug resistance |
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