| 隐丹参酮及其衍生物抗肿瘤活性研究进展 |
| 投稿时间：2022-08-22 修订日期：2023-03-15 点此下载全文 |
| 引用本文：温萍,张俊平.隐丹参酮及其衍生物抗肿瘤活性研究进展[J].药学实践杂志,2023,41(4):207~211 |
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| 基金项目:福建中医药大学高层次人才科研启动资金项目（X2019005） |
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| 中文摘要:隐丹参酮是中药丹参的有效成分之一，对多种肿瘤显示很好的活性。其抗肿瘤效应包括抑制细胞增殖、诱导肿瘤细胞凋亡、抑制细胞迁移和侵袭、调节机体免疫功能和逆转药物耐药性等。抗肿瘤直接靶点有信号转导和转录激活因子3（STAT3）、酪氨酸蛋白磷酸酶SHP2、DNA拓扑异构酶2（top2) ，其它的作用机制包括诱导活性氧（ROS）产生、调控雌、雄激素受体信号、抑制PI3K/AKT信号通路等。此外，近年来研究人员还设计合成了许多隐丹参酮衍生物，并对其抗肿瘤作用进行了研究。本文主要就隐丹参酮及其衍生物抗肿瘤活性研究进展进行综述，希望能够有助于隐丹参酮及其衍生物在抗肿瘤方面的药物研发。 |
| 中文关键词:隐丹参酮 衍生物 抗肿瘤 机制 |
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| Progress on the antitumor activity of cryptotanshinone and its derivatives |
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| Abstract:Cryptotanshinone is one of the effective components of traditional Chinese medicine salvia miltiorrhiza which shows good activities against a variety of tumors. Its anti-tumor effects include inhibition of tumor cell proliferation, induction of cell apoptosis, inhibition of cell migration and invasion, regulation of immune function and reversal of drug resistance. The direct anti-tumor targets include signal transducer and activator of transcription 3 (STAT3), tyrosine protein phosphatase SHP2, DNA topoisomerase 2, and other mechanisms of action include the induction of reactive oxygen species (ROS) production, regulation of estrogen and androgen receptor signaling, and inhibition of PI3K/AKT signaling pathway. In addition, many cryptotanshinone derivatives have been designed and synthesized to study the antitumor effects. The research progress of the antitumor activity of cryptotanshinone and its derivatives were reviewed in this paper to give references to the anti-tumor drug development of cryptotanshinone and its derivatives. |
| keywords:cryptotanshinone derivatives anti-tumor mechanism |
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