青藏高原肺结核合并念珠菌感染患者的病原菌分布特点及耐药率分析
投稿时间:2023-04-11  修订日期:2024-03-07  点此下载全文
引用本文:史生辉,石飞,雷琼,王亚峰,吴雪花.青藏高原肺结核合并念珠菌感染患者的病原菌分布特点及耐药率分析[J].药学实践杂志,2024,42(6):260~262,272
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作者单位E-mail
史生辉 青海省人民医院药学部, 青海 西宁 810007  
石飞 青海省人民医院药学部, 青海 西宁 810007  
雷琼 青海省第四人民医院药学部, 青海 西宁 810007  
王亚峰 青海省人民医院药学部, 青海 西宁 810007  
吴雪花 青海省人民医院药学部, 青海 西宁 810007 wxh_8284@163.com 
基金项目:青海省卫健委重点课题(2022-wjzd-01);青海省卫健委指导性课题(2022-wjzdx-13)
中文摘要:目的 研究青藏高原肺结核患者中机会性念珠菌病原学分布特点及耐药情况。方法 分析2020年3月1日至2020年12月31日青海省第四人民医院3 012例住院肺结核患者,收集痰标本,采用VITEK-32-YBC全自动细菌分析系统进行念珠菌鉴定,并对检出的念珠菌进行药敏试验。结果 在本次调查的3 012例肺结核患者中,合并念珠菌感染的肺结核患者有283例,占9.40%。其中,念珠菌类型又以白念珠菌为主,占总数的79.86%。结论 青藏高原地区肺结核合并念珠菌感染的患病率较高。因此,选择抗菌药物要根据患者的情况综合分析,以此来选择最佳、最有效的药物治疗方法。
中文关键词:肺结核  念珠菌  病原学  耐药率
 
Distribution characteristics and drug resistance rate of pathogenic bacteria in patients with pulmonary tuberculosis combined with Candida infection on the Tibetan plateau
Abstract:Objective To investigate the pathogenic distribution characteristics and drug resistance of opportunistic Candida in patients with pulmonary tuberculosis on the Qinghai-Tibet Plateau. Methods 3 012 hospitalized cases of pulmonary tuberculosis at Qinghai Province Fourth People’s Hospital from March 1, 2020 to December 31, 2020 were analyzed, sputum samples were collected, Candida identification was carried by VITEK-32-YBC automatic bacterial analysis system, and the detected Candida was tested for drug sensitivity. Results Among the 3 012 cases of pulmonary tuberculosis in this investigation, 283 cases of pulmonary tuberculosis patients with Candida infection, accounting for 9.40%. Among them, Candida albicans was the main type of Candida, accounting for 79.86% of the total. Conclusion The prevalence rate of pulmonary tuberculosis complicated with Candida infection was high in Qinghai-Tibet Plateau. Therefore, the selection of antimicrobial drugs should be based on a comprehensive analysis of the patient's condition, in order to select the best and most effective drugs for treatment.
keywords:pulmonary tuberculosis  Candida  etiology  drug resistance
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