89例细菌性肝脓肿的临床特征及抗感染治疗分析
投稿时间:2023-02-22  修订日期:2023-05-11  点此下载全文
引用本文:张晶晶,索丽娜,郑兆红.89例细菌性肝脓肿的临床特征及抗感染治疗分析[J].药学实践杂志,2024,42(6):267~272
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作者单位
张晶晶 青岛市第八人民医院药学部, 山东 青岛 266000 
索丽娜 青岛市第八人民医院药学部, 山东 青岛 266000 
郑兆红 青岛市第八人民医院药学部, 山东 青岛 266000 
中文摘要:目的 分析探讨细菌性肝脓肿的临床特征、抗菌药物合理使用情况和疗程。方法 回顾青岛市第八人民医院2020年1月1日至2022年12月31日诊断为“细菌性肝脓肿”患者的临床资料,总结临床特征,制定评价标准对抗菌药物合理性进行评价,统计不同治疗结局抗菌药物的使用疗程。结果 共89例患者纳入分析,平均年龄(62.0±15.6)岁,男性占61.8%,最常见合并症为糖尿病,占53.9%。59例(66.3%)脓液或血培养阳性患者中,肺炎克雷伯菌51例(57.3%)。经验和目标抗感染治疗中,分别有45例(50.6%)和17例(28.8%)抗菌药物使用不合理。痊愈抗感染疗程(17.0±7.6) d,临床实际抗感染疗程(21.1±7.3) d。结论 糖尿病为细菌性肝脓肿的高危因素,以肺炎克雷伯菌感染为主。应加强抗菌药物的管理,探索适宜抗感染疗程,减少抗菌药物的过度使用。
中文关键词:细菌性肝脓肿  临床特征  抗菌药物  评价  疗程
 
Analysis of clinical characteristics and anti-infection treatment of 89 cases with pyogenic liver abscess
Abstract:Objective To analyze the clinical characteristics of pyogenic liver abscess(PLA)and explore the rationality and the duration of antibacterial treatment. Methods The clinical data of patients diagnosed as pyogenic liver abscess in our hospital from January 1,2020 to December 31,2022 were analyzed to explore their clinical characteristics. The rationality of antibacterial treatment was evaluated by setting evaluation criteria. The duration of antibacterial use in different treatment outcomes was counted.Results A total of 89 patients were included in the analysis. The average age was (62.0±15.6) years old, with the male accounting for 61.80%. Diabetes for 53.9% was the most common complication. Among 59 patients (66.3%)with positive culture of pos or blood, 51 cases (57.3%) were Klebsiella Pneumoniaes. Among the empirical and target treatment, 45 cases (50.6%) and 17 cases (28.8%)of antibacterial regimens were evaluated as unreasonable, respectively. Recovery treatment time was (17.0±7.6)d,and actual treatment time was (21.1±7.3) d. Conclusion Diabetes was the most common high-risk factor of PLA, and Klebsiella Pneumoniae was the main pathogenic bacteria. It is necessary to strengthen the management of antibacterial drugs, explore the appropriate duration of antibacterial treatment, and reduce the overuse of antibacterial drugs.
keywords:pyogenic liver abscess  clinical characteristics  antibiotics  evaluation  treatment time
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