| 雌激素干预的EPCs移植对糖尿病缺血性脑卒中大鼠的治疗作用 |
| 投稿时间：2021-11-30 修订日期：2022-04-19 点此下载全文 |
| 引用本文：董雅芬,王建,陈业,李姝姝,刘河龙,邱彦.雌激素干预的EPCs移植对糖尿病缺血性脑卒中大鼠的治疗作用[J].药学实践杂志,2023,41(1):40~44,49 |
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| 基金项目:浦东新区卫生健康委员会领先人才培养项目(PRWL2020-08); 上海市浦东新区人民医院科技项目(E17-04) |
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| 中文摘要:目的 探讨雌激素干预的EPCs移植对糖尿病缺血性脑卒中的治疗作用。方法 制备大鼠糖尿病缺血性脑卒中模型，24 h后通过尾静脉移植经PKH26标记的糖尿病EPCs和雌激素干预的糖尿病EPCs。移植3 d后测定各组大鼠脑缺血体积、大鼠行为学变化、缺血部位血管新生及EPCs的归巢情况。结果 与糖尿病脑缺血大鼠相比，雌激素干预的糖尿病EPCs移植能降低脑缺血体积、改善行为学评分和缺血部位的血管新生及促进EPCs归巢到损伤部位(P<0.05)。结论 雌激素干预的糖尿病EPCs移植，通过促进EPCs归巢和血管新生对糖尿病缺血性脑卒中有较好的治疗作用。 |
| 中文关键词:雌激素 内皮祖细胞移植 糖尿病缺血性脑卒中 血管新生 归巢 |
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| Therapeutic effects of estrogen-intervened EPCs transplantation on diabetic ischemic stroke rats |
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| Abstract:Objective To explore the therapeutic effects of estrogen-intervened endothelial progenitor cells( EPCs) transplantation on diabetic ischemic stroke rats. Methods PKH26-labeled diabetic EPCs and estrogen-intervened diabetic EPCs were injected into rats via the tail vein 24 h after cerebral ischemia. Cerebral ischemic volume, behavioral changes, ischemic site vascularization and homing of EPCs were measured 3 d after EPCs injection. Results Compared with diabetic ischemic rats, estrogen-intervened EPCs transplantation had reduced infarct volumes, improved behavioral scores and ischemic site revascularization and promoted homing of EPCs to sites of injury(P<0.05). Conclusion Estrogen-intervened EPCs transplantation had a better therapeutic effect on diabetic ischemic stroke by promoting EPCs homing to injury site and EPCs-medicated neovascularization . |
| keywords:estrogen EPCs transplantation diabetic ischemic stroke neovascularization homing |
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