昆仙胶囊联合坎地沙坦酯治疗慢性肾炎合并高血压疗效观察
投稿时间:2021-05-24  修订日期:2022-01-05  点此下载全文
引用本文:赵琳娜,刘丽,李洪艳,孙文才,武文,董雪斌.昆仙胶囊联合坎地沙坦酯治疗慢性肾炎合并高血压疗效观察[J].药学实践杂志,2022,40(5):481~484
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作者单位
赵琳娜 陆军第八十一集团军医院肾脏病区, 河北 张家口 075000 
刘丽 陆军第八十一集团军医院肾脏病区, 河北 张家口 075000 
李洪艳 陆军第八十一集团军医院肾脏病区, 河北 张家口 075000 
孙文才 陆军第八十一集团军医院肾脏病区, 河北 张家口 075000 
武文 陆军第八十一集团军医院肾脏病区, 河北 张家口 075000 
董雪斌 陆军第八十一集团军医院肾脏病区, 河北 张家口 075000 
基金项目:2019年度张家口市级科技计划自筹经费项目(1921118D)
中文摘要:目的 探讨昆仙胶囊联合坎地沙坦酯对慢性肾炎合并高血压患者的血压、肾功能、血脂及炎症因子的影响。方法 选择2017年11月至2019年12月在本院收治的101名慢性肾小球肾炎患者,将患者随机分为观察组(51例)和对照组(50例)。对照组在常规治疗的基础上使用坎地沙坦酯治疗,观察组在对照组的基础上使用昆仙胶囊治疗,比较两组的临床疗效及不良反应。结果 观察组总有效率显著高于对照组(P<0.05),两组治疗后血压、肾功能指标(24 h Upro、BUN、Scr)、血脂指标(TG、TC、LDL-C)、炎症因子(IL-6、hs-CRP)均显著降低,且观察组显著低于对照组(P<0.05)。治疗后两组血脂指数HDL-C显著升高,且观察组血脂指数HDL-C显著高于对照组(P<0.05)。结论 昆仙胶囊联合坎地沙坦酯治疗慢性肾炎合并高血压患者可提高临床疗效,改善肾功能,调节血脂,减轻炎症反应。
中文关键词:慢性肾炎  高血压  昆仙胶囊  坎地沙坦酯  临床疗效
 
Observation on the effect of Kunxian capsule combined with candesartan cilexetil in the treatment of chronic nephritis with hypertension
Abstract:Objective To investigate the effect of Kunxian capsule combined with candesartan axetil on blood pressure, renal function, blood lipids and inflammatory factors in patients with chronic glomerulonephritis complicated with hypertension. Methods 101 patients with chronic glomerulonephritis who were admitted to our hospital from November 2017 to December 2019 were selected and randomly divided into observation group (51 cases) and control group (50 cases). The control group was treated with candesartan cilexetil on the basis of conventional treatment, and the observation group was treated with Kunxian capsule on the basis of the control group. The clinical efficacy and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). After treatment, the blood pressure, renal function indexes (24 h Upro, BUN, Scr), blood lipid indexes (TG, TC, LDL-C), and inflammatory factors of the two groups (IL-6, hs-CRP) significantly decreased, and the observation group was significantly lower than the control group (P<0.05). After treatment, the blood lipid index HDL-C of the two groups increased significantly, and the blood lipid index HDL-C of the observation group was significantly higher than that of the control group (P<0.05). Conclusion Kunxian capsule combined with candesartan axetil can enhance the clinical efficacy, improve renal function, regulate blood lipids and reduce inflammation in patients with chronic glomerulonephritis complicated with hypertension.
keywords:chronic glomerulonephritis  hypertension  Kunxian capsule  candesartan axetil  clinical effect
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