中性粒细胞和淋巴细胞比值联合B型利钠肽对老年心力衰竭合并肺部感染的预测价值
投稿时间:2021-12-04  修订日期:2022-08-23  点此下载全文
引用本文:张洁,巢胜吾,杨积顺.中性粒细胞和淋巴细胞比值联合B型利钠肽对老年心力衰竭合并肺部感染的预测价值[J].药学实践杂志,2022,40(5):469~472
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作者单位E-mail
张洁 复旦大学校医院, 上海 200433  
巢胜吾 海军特色医学中心心内科, 上海 200052  
杨积顺 海军特色医学中心医疗保障中心, 上海 200052 jasunyang@foxmail.com 
中文摘要:目的 评估中性粒细胞和淋巴细胞比值(NLR)联合B型利钠肽(BNP)对老年心力衰竭合并肺部感染病人中的预测价值。方法 收集2018年6月至2020年5月我院就诊的老年心力衰竭病人178例,其中合并肺部感染组92例,无肺部感染组86例。比较两组NLR和BNP水平以及其他临床指标的差异,采用Logistic分析NLR和BNP水平对心力衰竭伴发肺部感染的影响,ROC曲线分析NLR联合BNP对老年心力衰竭合并肺部感染的预测价值。结果 Logistic回归分析显示NLR(OR=7.606,95%CI: 3.123~18.526)和BNP(OR=4.264,95%CI: 1.682~10.811)是老年心力衰竭合并肺部感染的独立危险因素。Pearson相关分析显示BNP水平与NLR水平呈正相关(r=0.400, P<0.001)。NLR、BNP和NLR+BNP联合预测老年心力衰竭合并肺部感染ROC曲线下面积分别为0.810、0.756和0.838。结论 BNP和NLR是老年心力衰竭合并肺部感染的独立危险因素,联合检测对其发生有较好的预测价值。
中文关键词:心力衰竭  肺部感染  中性粒细胞和淋巴细胞比值  B型利钠肽
 
Predictive value of neutrophil to lymphocyte ratio combined with BNP in elderly patients with heart failure complicated with pulmonary infection
Abstract:Objective To evaluate the predictive value of neutrophil to lymphocyte ratio(NLR) and B-type natriuretic peptide (BNP) in elderly patients with heart failure complicated with pulmonary infection. Methods 178 heart failure patients in our hospital from June 2018 to May 2020 were selected as the research objects, and they were divided into pulmonary infection group (n=92) and non-pulmonary infection group (n=86) according to whether they were complicated with pulmonary infection. The differences of NLR and BNP levels and other clinical indicators between the two groups were compared. Univariate and multivariate Cox regression were used to analyze the influence of NLR and BNP levels on heart failure complicated with pulmonary infection. The predictive value of NLR combined with BNP on heart failure complicated with pulmonary infection was analyzed by receiver operating characteristic (ROC) curve. Results Multivariate logistic regression analysis showed that NLR (OR=7.606, 95% CI: 3.123-18.526) and BNP (OR=4.264, 95% CI: 1.682-10.811) were independent risk factors of elderly heart failure complicated with pulmonary infection after adjusting for other related variables. Pearson correlation analysis showed that BNP level was positively correlated with NLR level (r=0.400, P<0.001). The area under ROC curve of NLR, BNP and NLR+BNP in predicting pulmonary infection in elderly patients with heart failure was 0.810, 0.756 and 0.838, respectively. Conclusion BNP and NLR are independent risk factors of elderly patients of heart failure with pulmonary infection .The combined detection of BNP and NLR has predictive value for those patients.
keywords:heart failure  pulmonary infection  NLR  BNP
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