刺梨特征图谱及质量标准研究
投稿时间:2021-06-20  修订日期:2021-12-24  点此下载全文
引用本文:张成中,郑承剑,何旭辉,王宏瑞,黄宝康,卜其涛.刺梨特征图谱及质量标准研究[J].药学实践杂志,2022,40(5):464~468
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作者单位E-mail
张成中 海军军医大学药学院, 上海 200433  
郑承剑 海军军医大学药学院, 上海 200433  
何旭辉 海军军医大学药学院, 上海 200433  
王宏瑞 海军军医大学药学院, 上海 200433  
黄宝康 海军军医大学药学院, 上海 200433 hbk@smmu.edu.cn 
卜其涛 海军军医大学药学院, 上海 200433 bujenny@163.com 
基金项目:安徽省食品药品监督管理局中药材标准项目
中文摘要:目的 制定刺梨药材质量标准,用于刺梨的生产、监督、流通及使用等各环节的质量控制。方法 参照《中国药典》通用检测方法及相关指导原则分别制定刺梨的水分、总灰分、浸出物限度;采用特征图谱以及薄层色谱法控制刺梨整体质量。结果 刺梨特征图谱中应呈现6个特征峰,并应与对照药材参照物色谱峰中的5个特征峰保留时间相对应,另有1峰应与加入的异槲皮苷对照品参照物峰保留时间相对应。水分不得过14.0%,总灰分不得过5.0%,醇溶性浸出物不少于20.0%。结论 实验所建立的刺梨质量标准符合国家有关中药质量标准制定要求,能够以标准的形式对刺梨的质量进行控制。
中文关键词:刺梨  特征图谱  质量标准
 
Study on quality standard and characteristic chromatogram for Hirtula Roses
Abstract:Objective To establish the quality standards of Hirtula Roses for the quality control of production, supervision, circulation and application. Methods The moisture content, total ash, ethanol extract content and characteristic chromatogram of Rosa roxburghii Tratt. were determined according to the related determination method in Ⅳ-Part of Chinese Pharmacopeia 2020. Results There should be 6 characteristic peaks in the characteristic chromatogram of Rosa roxburghii Tratt., which should correspond to the retention time of 5 characteristic peaks in the reference chromatogram of the standard herbs, and another peak should correspond to the retention time of the reference chromatogram of isoquercitrin. The moisture content of Rosa roxburghii Tratt. should be less than 14.0%; the total ash content should be less than 5.0%; the ethanol extract content should be more than 20.0%. Conclusion According to the experimental results, the quality standard of Rosa roxburghii Tratt. is conformed to the national requirements of quality standards for traditional Chinese medicine, which could provide a reference for the quality control of Hirtula Roses.
keywords:Rosa roxburghii Tratt.  characteristic chromatogram  quality standard
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