肠道菌群相关的抗抑郁治疗研究进展
投稿时间:2021-11-06  修订日期:2022-02-13  点此下载全文
引用本文:王倩男,黄心慧,杨民绪,杨星瑞,朱可涵,周婷婷.肠道菌群相关的抗抑郁治疗研究进展[J].药学实践杂志,2022,40(5):422~426
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作者单位E-mail
王倩男 海军军医大学药学院, 上海 200433  
黄心慧 海军军医大学药学院, 上海 200433  
杨民绪 海军军医大学药学院, 上海 200433  
杨星瑞 海军军医大学药学院, 上海 200433  
朱可涵 海军军医大学药学院, 上海 200433  
周婷婷 海军军医大学药学院, 上海 200433
上海市药物(中药)代谢产物研究重点实验室, 上海 200433 
tingting_zoo@163.com 
基金项目:国家自然科学基金(81973457,81773862)
中文摘要:目的 介绍肠道菌群与抑郁症的病理机制以及相关治疗的研究进展,为后续以肠道菌为靶点的抗抑郁药物的研发提供帮助。方法 查阅近年来肠道菌群与抑郁症方面的33篇中英文文献进行分类总结,从肠道菌群的门、科、属水平的角度探讨了抑郁状态下肠道菌群多样性的变化,从分子水平上阐述了肠道菌与抑郁症发病机制之间的关系,总结现有相关研究,进一步探索以肠道菌群为靶点进行药物研发治疗的可行性。结果 肠道菌紊乱与抑郁症之间相互作用,现有益生菌等生物制剂可通过改善肠道菌群病理状态下的紊乱对抑郁症治疗起到缓解作用。结论 肠道菌群失调与抑郁的发生密切相关,以肠道菌为靶点的相关药物研发治疗,可能成为治疗抑郁症的新途径。
中文关键词:抑郁症  肠道菌群  菌-肠-脑轴
 
Advances in antidepressant therapy related to gut microbiota
Abstract:Objective This paper introduces the research progress on the pathogenesis of depression related to gut microbiota and provides the resources for the subsequent development of antidepressant drugs targeting gut microbiota. Methods 33 literatures on gut microbiota and depression in recent years were reviewed. The changes of gut microbiota diversity under depression were discussed from the perspectives of phylum, family and genus. The relationship between gut microbiota and the pathogenesis of depression was expounded at the molecular level, and the existing relevant studies were summarized. The feasibility of drug development targeting gut microbiota was explored. Results There is a relationship between gut microbiota disorder and depression. Existing biological agents such as probiotics can alleviate depression by adjusting the disorder of gut microbiota. Conclusion The imbalance of gut microbiota is closely related to the occurrence of depression, and the development of drugs targeting gut microbiota may become a new way to treat depression.
keywords:depression  gut microbiota  microbiome-gut-brain axis
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