高原低氧环境下硝苯地平控释片对高血压患者降压作用的临床研究
投稿时间:2022-05-30  修订日期:2022-09-01  点此下载全文
引用本文:黄琴,高子昭,尼样卓玛,索南格勒,王荣.高原低氧环境下硝苯地平控释片对高血压患者降压作用的临床研究[J].药学实践杂志,2022,40(5):395~398
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黄琴 中国人民解放军联勤保障部队第九四〇医院药剂科, 甘肃 兰州 730050
兰州大学 药学院, 甘肃 兰州 730000 
 
高子昭 中国人民解放军联勤保障部队第九四〇医院药剂科, 甘肃 兰州 730050  
尼样卓玛 青海玉树州玉树市八一医院内科病区, 青海 玉树 815000  
索南格勒 青海玉树州人民医院内科, 青海 玉树 815000  
王荣 中国人民解放军联勤保障部队第九四〇医院药剂科, 甘肃 兰州 730050
兰州大学 药学院, 甘肃 兰州 730000 
wangrong-69@163.com 
基金项目:国家自然科学基金(81673508, 82173738);中央高校基本科研业务费专项(3192020009);甘肃省青年科技基金计划(20JR10RA014);联勤保障部队第九四〇医院院内应急医学科研项目(20yjky017)
中文摘要:目的 考察高原低氧环境下硝苯地平控释片对高血压患者降压疗效及安全性评价。方法 将42例第九四〇医院高血压住院患者(海拔1 500 m)设为平原高血压组,42例八一医院高血压住院患者(海拔3 800 m)设为高原高血压组。两组患者均每日给予硝苯地平控释片30 mg,晨起口服,连续治疗6 d。每日监测3次血压和心率,观察两组患者的临床疗效及药物不良反应的发生情况。结果 经治疗后,高原高血压组和平原高血压组的总有效率分别为47.62%(20例/42例)和76.19%(32例/42例),差异有统计学意义(P<0.05)。观察到两组患者的药物不良反应均为心动过速及心悸,高原高血压组和平原高血压组的总药物不良反应发生率分别为14.29%和11.90%,差异无统计学意义(P>0.05)。结论 高原低氧环境下硝苯地平控释片的降压疗效下降,未能有效控制高原地区高血压患者短期内的血压。
中文关键词:硝苯地平控释片  高原低氧  高血压  临床疗效
 
Clinical trial of nifedipine controlled-release tablets on reducing blood pressure in the treatment of patients with hypertension at high altitude
Abstract:Objective To observe the clinical efficacy and safety of nifedipine controlled-release tablets on the antihypertensive effect of hypertensive patients under high altitude environment. Methods 42 hypertensive inpatients in the 940th hospital (altitude 1500 ) were set to the plain hypertension group, and 42 cases of hypertensive inpatients in Bayi hospital (altitude 3800 m) were set to the plateau hypertension group. Both groups of patients were given nifedipine controlled-release tablets 30 mg daily, taken orally in the morning for 6 consecutive days. Monitor blood pressure and heart rate three times a day to compare the clinical efficacy and occurrence of adverse drug reactions in the two groups. Results After treatment, the total effective rates of the high-altitude hypertension group and the plain hypertension group were 47.62% (20 cases/42 cases) and 76.19% (32 cases/42 cases) respectively with no statistical difference (P<0.05). The adverse drug reactions of the two groups of patients were tachycardia and palpitations. The incidence of total adverse drug reactions in the high-altitude hypertension group and the plain hypertension group were 14.29% and 11.90% respectively with no statistical difference (P>0.05). Conclusion The high-altitude hypoxic environment could affect the antihypertensive effect of nifedipine controlled-release tablets, which could not control the patient's blood pressure effectively in the short term.
keywords:nifedipine controlled-release tablet  high altitude hypoxia  hypertension  clinical efficacy
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