1例儿童细菌性脑膜炎的治疗分析与药学监护
投稿时间:2020-12-22  修订日期:2021-03-07  点此下载全文
引用本文:刘婷,曹忠强,湛敏,张洲,吴越,李学娟,陈泽彬.1例儿童细菌性脑膜炎的治疗分析与药学监护[J].药学实践杂志,2021,39(2):174~177
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作者单位E-mail
刘婷 深圳市儿童医院广东 深圳 518038  
曹忠强 深圳市儿童医院广东 深圳 518038  
湛敏 深圳市儿童医院广东 深圳 518038  
张洲 深圳市儿童医院广东 深圳 518038  
吴越 深圳市儿童医院广东 深圳 518038  
李学娟 深圳市儿童医院广东 深圳 518038  
陈泽彬 深圳市儿童医院广东 深圳 518038 13602602625@qq.com 
中文摘要:目的 探讨儿童细菌性脑膜炎药物治疗及药学监护的策略。方法 借助相关指南及文献,对1例儿童细菌性脑膜炎的抗感染治疗、万古霉素的血药浓度监测(TDM)和剂量调整进行分析及讨论,向临床医生提供药物治疗措施和建议。结果 通过对儿童细菌性脑膜炎的用药分析,结合病原学及药敏结果停用美罗培南,加用利福平;根据万古霉素监测浓度,延长其输注时间以达目标范围,医生部分采纳临床药师建议,患者病情好转出院。结论 临床药师应依据药物治疗相关指南及最新研究证据为临床提供用药建议,以促进临床用药合理有效。
中文关键词:细菌性脑膜炎  抗感染  血药浓度监测  药学监护  儿童
 
Treatment analysis and pharmaceutical care for one child with bacterial meningitis
Abstract:Objective To explore the strategies of drug treatment and pharmaceutical care for children with bacterial meningitis.Methods The anti-infective therapy, therapeutic drug monitoring and dose adjustment of vancomycin in children with bacterial meningitis were analyzed and discussed according to relevant guidelines and literatures.Results Clinical pharmacists analyzed therapeutic regimen. According to the results of etiology and drug sensitivity, meropenem was discontinued and rifampicin was added. Based on drug monitoring of vancomycin, it is suggested to extend the infusion time of vancomycin to reach the target concentration. The child was discharged from hospital.Conclusion Recommendations of the relevant drug treatment guidelines and the latest medical research evidence should be provided by clinical pharmacists in order to promote reasonable and effective clinical uses of medicine.
keywords:bacterial meningitis  anti-infection  therapeutic drug monitoring  pharmaceutical care  children
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