| 万古霉素致腹膜透析患者全血细胞减少的用药分析与不良反应监护 |
| 投稿时间：2020-08-15 修订日期：2021-01-14 点此下载全文 |
| 引用本文：章斌,董云玲,解莹馨,李悦悦,焦秀秀,原永芳.万古霉素致腹膜透析患者全血细胞减少的用药分析与不良反应监护[J].药学实践杂志,2021,39(2):169~173 |
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| 基金项目:上海交通大学医学院附属第九人民医院种子基金（JYZZ063）；上海市临床药学重点专科经费资助 |
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| 中文摘要:目的 为临床药师参与腹膜透析相关性腹膜炎患者的抗感染治疗和个体化药学服务实践提供参考。方法 临床药师通过对1例腹膜透析患者万古霉素血药谷浓度的监测，根据腹透液细菌培养与药敏结果评价以调整抗感染治疗方案，并对万古霉素所致的全血细胞减少进行了不良反应监护。结果 有效控制了该腹膜透析患者的感染，全血细胞减少的相关指标有所好转。结论 通过对1例万古霉素致腹膜透析患者全血细胞减少的病例分析，以期引起临床工作人员对这一不良反应的关注，提高使用万古霉素的用药安全性。 |
| 中文关键词:万古霉素 腹膜透析 全血细胞减少 个体化治疗 药物副反应报告系统 |
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| Medication evaluation and adverse reaction monitoring in patient on peritoneal dialysis with pancytopenia induced by vancomycin |
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| Abstract:Objective To provide reference for anti-infection treatment and individual pharmaceutical care in patient on peritoneal dialysis.Methods The plasma concentration of vancomycin in patient on peritoneal dialysis was monitored by clinical pharmacists. The anti-infection treatment plan was evaluated and adjusted according to the bacterial culture and drug sensitivity results of the abdominal dialysis fluid. The adverse reactions of pancytopenia induced by vancomycin were documented.Results Infection in the patient on peritoneal dialysis was effectively controlled. The related indicators of pancytopenia were improved.Conclusion A case of pancytopenia induced by vancomycin in the patient on peritoneal dialysis was analyzed to get clinical staff's attention to this adverse reaction and improve the safety of vancomycin administration. |
| keywords:vancomycin peritoneal dialysis pancytopenia individualized treatment adverse drug reaction reporting system |
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