Smart Dose对万古霉素血药浓度的预测效能评价
投稿时间:2020-09-05  修订日期:2021-03-17  点此下载全文
引用本文:李燕,陈礼治,王学彬,杨云云,杨小琳,王卓.Smart Dose对万古霉素血药浓度的预测效能评价[J].药学实践杂志,2021,39(2):164~168,177
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作者单位E-mail
李燕 海军军医大学附属长海医院药学部上海 200433  
陈礼治 海军军医大学附属长海医院药学部上海 200433  
王学彬 海军军医大学附属长海医院药学部上海 200433  
杨云云 海军军医大学附属长海医院药学部上海 200433  
杨小琳 海军军医大学附属长海医院药学部上海 200433  
王卓 海军军医大学附属长海医院药学部上海 200433 wangzhuo088@163.com 
中文摘要:目的 评价个体化给药决策支持系统Smart Dose应用于中国人群治疗药物监测的临床效用。方法 使用Smart Dose系统预测患者万古霉素谷浓度,分析谷浓度预测值与实测值之间的差异,以评价该系统对于万古霉素血药浓度的预测效能。结果 Smart Dose调整浓度预测值与实测值之间的差异,平均百分比误差,平均绝对百分比误差小于初始浓度预测值与实测值之间的差异。神经外科组患者初始浓度预测值与实测值的差异比非神经外科组患者小,预测效能优于非神经外科组。高谷浓度组和低年龄组(<59岁)的初始浓度预测值更接近于实测值。不同的BMI对于初始浓度的预测效能相仿。结论 Smart Dose系统更适合于万古霉素调整浓度的预测。用于初始浓度预测时,神经外科组、高谷浓度及低年龄组的预测值更准确。不同的BMI对于初始浓度预测效能相仿。
中文关键词:万古霉素  治疗药物监测  个体化给药系统
 
Evaluation of Smart Dose's predictive effectiveness on vancomycin blood concentration
Abstract:Objective To evaluate clinical utility of the personalized drug delivery decision support system, Smart Dose, applied to the monitoring of therapeutic drugs in Chinese population.Methods Use Smart Dose system to predict the trough concentration of vancomycin in patients, analyze the difference between the predicted value and the measured value of the trough concentration, and to evaluate the prediction performance of the system for vancomycin blood concentration.Results Smart Dose adjusts the difference between the predicted value of concentration and the measured value, the average percentage error, and the average absolute percentage error is less than the difference between the predicted value of initial concentration and the measured value. The difference between the initial concentration prediction value and the measured value of the neurosurgery group was smaller than that of the non-neurosurgery group, and the prediction efficiency was better than that of the non-neurosurgery group. The predicted initial concentration of the high trough concentration group and the low-age group (<59 years old) are closer to the measured value. The predictive performance of different BMI for the initial concentration is similar.Conclusion Smart Dose system is more suitable for predicting the adjusted concentration of vancomycin; When used for initial concentration prediction, the prediction values of neurosurgery group, high trough concentration, and low age group are more accurate. Different BMI has similar performance in predicting initial concentration.
keywords:vancomycin  therapeutic drug monitoring  software
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