| 新型冠状病毒肺炎医学观察期中医治疗方案的不良反应分析 |
| 投稿时间：2020-07-06 修订日期：2020-08-19 点此下载全文 |
| 引用本文：李英,解方园,张菁,梁李娟,胡云英,张国庆.新型冠状病毒肺炎医学观察期中医治疗方案的不良反应分析[J].药学实践杂志,2020,38(5):404~408,434 |
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| 中文摘要:目的 分析《新型冠状病毒肺炎诊疗方案（试行第七版）》中推荐的新型冠状病毒医学观察期中医治疗方案不良反应（ADR）的特点和规律，为临床合理用药提供指导。方法 检索中国知网（CNKI）、万方数据库、PubMed数据库中有关9种中药方剂导致的ADR病例，对涉及的文献资料进行性别、年龄、发生时间、累及系统/器官、治疗转归、关联性评价等资料的提取与统计分析。结果 按纳入与排除标准，共纳入61篇文献，提取病例70例，涉及到5种中药方剂。男女比例未有明显偏向，年龄跨度大，发生时间大多发生在1 d以内，累及系统/器官广泛，以皮肤及其附件最多，治疗药物以抗组胺药和激素药为主，其他药物多为对症治疗，转归时间以1 h内最多，占47%。结论 医学观察期的中医治疗方案ADR发生人群分布广泛，未见明显特征，应用时应加强监测，以减少ADR的发生。 |
| 中文关键词:新型冠状病毒 医学观察期 中医 药物不良反应 |
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| Adverse drug reactions induced by traditional Chinese medicine treatment for new coronavirus pneumonia during the medical observation period |
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| Abstract:Objective To investigate the characteristics of the adverse drug reaction (ADR) in the traditional Chinese medicine (TCM) treatment followed the "COVID-19 Diagnosis and Treatment Program (trial version 7)" during the medical observation period, and to provide a guideline for rational clinical drug use.Methods 9 TCM induced ADR were collected from CNKI, Wanfang database and PubMed. Statistical analysis was conducted on gender, age, occurrence time, involved system/organ, treatment, outcome and relevance evaluation.Results 61 literatures were collected according to the inclusion and exclusion criteria with 70 cases and 5 TCM prescriptions. There was no significant bias in gender. The age span was large. Most ADR occurred within 1 day after administration. The involved systems/organs are extensive, mainly on the skin and its accessories. The most common therapeutic drugs were antihistamines and steroids, and other medications are mainly for symptom treatment. The turnaround time was 1 h in most cases (47%).Conclusions During the observation period, the incident population was widely distributed and there was no obvious characteristics. Medication monitoring should be reinforced to reduce the ADR incidence. |
| keywords:COVID-19 medical observation period TCM ADR |
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