| 腰痛宁胶囊联合依托考昔改善老年腰椎骨性关节炎痛感、炎症状态的临床效果 |
| 投稿时间：2019-12-30 修订日期：2020-03-05 点此下载全文 |
| 引用本文：李鹏飞,简强,乔美娜,孙长贵,高俊峰.腰痛宁胶囊联合依托考昔改善老年腰椎骨性关节炎痛感、炎症状态的临床效果[J].药学实践杂志,2020,38(4):368~372 |
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| 基金项目:昆山市社会发展科技项目（KS1416） |
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| 中文摘要:目的 观察腰痛宁胶囊联合依托考昔改善老年腰椎骨性关节炎痛感、炎症状态的临床效果。方法 将2016年1月至2018年6月就诊于战略支援部队特勤疗养中心的120例老年腰椎骨性关节炎患者，随机分为对照组和观察组各60例。对照组患者给予依托考昔治疗，观察组患者则在对照组基础上加服腰痛宁胶囊，两组患者均连续治疗2周。观察两组患者脊柱疼痛、生活质量评分变化；监测血清中炎症因子肿瘤坏死因子-α（TNF-α）、粒细胞-巨噬细胞集落刺激因子（GM-CSF）、环氧合酶（COX-2）、骨形态发生蛋白-2（BMP-2）水平，对比两组治疗的有效率，评价用药的安全性。结果 对照组与观察组患者的有效率分别为78.33%和91.67%，观察组显著优于对照组 (P<0.05)；治疗后，观察组患者的疼痛视觉模拟评分（VAS）较对照组明显降低（P<0.05），生活质量SF-36评分则明显升高（P<0.05），血清中TNF-α、GM-CSF、COX-2水平均较对照组明显降低（P<0.05），BMP-2水平则明显升高（P<0.05）。结论 腰痛宁胶囊联合依托考昔治疗老年腰椎骨性关节炎疗效确切，能显著减轻腰痛感，改善生活质量，抑制炎性反应，具有较高的用药安全性，值得临床深入探究。 |
| 中文关键词:腰痛宁胶囊 依托考昔 老年 腰椎骨性关节炎 痛感 炎症状态 |
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| The clinical effect of Yaotongning capsule combined with etoricoxib in the treatment of lumbar pain and inflammatory status in elderly patients with lumbar osteoarthritis |
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| Abstract:Objective To study the clinical effect of Yaotongning capsule combined with etoricoxib for the pain and inflammation of lumbar vertebrae in elderly patients with lumbar osteoarthritis.Methods 120 elderly patients with lumbar osteoarthritis admitted to our hospital from January 2016 to June 2018 were randomly divided into the control group and the observation group, with 60 patients in each group. Patients in the control group were treated with etoricoxib, while patients in the observation group were treated with etoricoxib plus Yaotongning capsule orally. Both groups received medications for 2 weeks. Spinal pain and quality of life score changes were recorded. The inflammatory cytokines in serum TNF-α, GM-CSF, COX-2 and BMP-2 levels were monitored. The clinical efficacy was compared and drug safety profile was evaluated for two groups.Results The effective rates of the control group and the observation group were 78.33% and 91.67% respectively. The effective rate in the observation group weas significantly higher (P<0.05). After treatment, the VAS score for the patients in the observation group was significantly lower than that in the control group (P<0.05). The SF-36 score in the observation group was significantly increased (P<0.05), and the levels of TNF-α,GM-CSF and COX-2 in the serum were significantly lower than those in the control group (P<0.05), and the levels of BMP-2 were significantly increased (P<0.05).Conclusion Yaotongning capsule combined with etoricoxib in the treatment of senile lumbar osteoarthritis has definite curative effect. It significantly reduced lumbar pain, improved quality of life, inhibited inflammatory reaction, and had a better drug safety profile. The further clinical investigation for the combination therapy is warranted. |
| keywords:Yaotongning capsule etoricoxib old age lumbar osteoarthritis lumbar pain inflammatory state |
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