| 基于网络药理学的金振口服液干预新冠肺炎的机制研究 |
| 投稿时间：2020-03-25 修订日期：2020-04-19 点此下载全文 |
| 引用本文：蔡孟成,俞超芹.基于网络药理学的金振口服液干预新冠肺炎的机制研究[J].药学实践杂志,2020,38(3):193~201 |
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| 基金项目:国家自然科学基金项目（81573585） |
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| 中文摘要:目的 探讨金振口服液治疗新型冠状病毒肺炎（COVID-19）的分子靶点及可能机制。方法 利用中药系统药理学数据库和分析平台（TCMSP）筛选金振口服液潜在的入血活性成分与靶点。通过GeneCard数据库检索COVID-19相关的靶点。利用String构建公共靶点的蛋白互作网络。利用Bioconductor数据库进行GO与KEGG富集分析。结果 根据口服生物利用度和药物相似性筛选出141种有效成分。从GeneCard数据库中获得350个与COVID-19直接相关的靶基因，从组分靶点与疾病靶点PPI网络的交叉点获得47个基因。这些基因主要参与细胞内脂多糖反应、氧化应激反应等生物学过程。分子功能主要与细胞因子受体结合、细胞因子活性、受体配体活性等有关。活性物质主要作用于IL-17信号通路、TNF信号通路、甲型流感等信号通路。结论 金振口服液中的化合物可能通过抗病毒、抗炎对新冠病毒导致的感染、炎症以及肺损伤疾病具有潜在的治疗作用。 |
| 中文关键词:金振口服液 新型冠状病毒肺炎 网络药理学 |
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| Mechanism of Jinzhen oral liquid in treatment of coronavirus disease 2019 based on network pharmacology |
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| Abstract:Objective To explore the molecular targets and related potential pathways of Jinzhen oral liquid in the treatment of coronavirus disease 2019 (COVID-19).Methods The potential blood-entry active ingredients and targets of Jinzhen oral liquid were retrieved by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). COVID-19 related gene targets were retrieved through GeneCard. Protein-protein interaction network of common targets was constructed by String. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway analysis of the intersection network were conducted by Bioconductor Database.Results 141 active ingredients were screened according to oral bioavailability and drug similarity. 350 target genes directly related to COVID-19 were obtained from the GeneCard. 47 genes were obtained from the intersection of component-target and disease-target. These genes were mainly involved in response to lipopolysaccharide, oxidative stress and other biological processes. Molecular functions were mainly related to cytokine receptor binding, cytokine activity, receptor ligand activity, etc. The active ingredients were related to IL-17 signaling pathway, TNF and Influenza A signaling pathway, etc.Conclusion The possible active compounds of Jinzhen oral liquid could be anti-viral and anti-inflammatory that could have potential therapeutic effect against virus infection, lung injury and inflammation caused by SARS-CoV-2. |
| keywords:Jinzhen oral liquid COVID-19 network pharmacology |
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