| 用气相色谱法测定血液制品生产过程中中间品乙醇的含量 |
| 投稿时间：2018-12-12 修订日期：2019-04-02 点此下载全文 |
| 引用本文：盛凤仙,李萍.用气相色谱法测定血液制品生产过程中中间品乙醇的含量[J].药学实践杂志,2019,37(5):464~465,469 |
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| 中文摘要:目的 建立气相色谱法测定血液制品生产过程中中间品乙醇含量的方法。方法 采用DB-624毛细管色谱柱，FID检测器，气化室温度230℃；检测器温度280℃；柱温：40℃，保持5 min后，以10℃/min升温至80℃，再以50℃/min升温至230℃，保持3 min；以正丙醇为内标。结果 乙醇在0.5%~5%浓度范围内线性关系良好（r=1.000 0），平均回收率为99.28%，RSD为0.01%（n=9）。结论 该方法简单灵敏，结果准确可靠，可用于血液制品生产过程中对中间品乙醇含量的测定。 |
| 中文关键词:中间品 乙醇 血液制品 气相色谱法 测定 |
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| Determination of ethanol content in intermediate products during the production of blood products by GC |
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| Abstract:Objective To establish a method for determination of ethanol content in intermediate products during the production of blood products by GC.Methods DB-624 column was used with FID detection.The temperature of the injector and detector was 230℃,280℃,respectively.The column temperature was kept at 40℃ for 5 minutes,then increased to 80℃ at 10℃ per minute,and finally to 230℃ at 50℃ per minute for 3 minutes.N-propanol was used as the internal standard.Results The standard curve was linear in the range of 0.05%-5%(r=1.000 0) for ethanol.The average recovery was 99.28% with RSD of 0.01%(n=9).Conclusion This method was simple,sensitive,accurate and reliable.It is suitable for the determination of ethanol content in intermediate products during the production of blood products. |
| keywords:intermediate products ethanol blood products GC determination |
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