| 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展 |
| 投稿时间：2019-04-04 修订日期：2019-06-11 点此下载全文 |
| 引用本文：丁佳宁,马进原,朱全刚.长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J].药学实践杂志,2019,37(5):390~393,421 |
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| 基金项目:国家自然科学基金（81472394）；上海市皮肤病医院国家自然科学基金培育项目（17GZRPY11） |
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| 中文摘要:长链非编码RNA（long non-coding RNA，lncRNA）覆盖了人类DNA的大部分非编码信息，占整个基因组的90%以上，它们构成了一个广泛而复杂的分子群，在肿瘤的病理生理过程中以多种形式存在。2003年，lncRNA人母系表达基因（MEG）3被证明是垂体瘤的一个潜在的肿瘤抑制因子，之后研究者又在脑膜瘤、肝癌、肺癌、神经内分泌瘤，以及前列腺癌等其他肿瘤上对其在基因表达调控、印记、转录和翻译后的作用上进行了研究，发现MEG3在多种恶性肿瘤组织中低表达或表达缺失，而上调MEG3的表达与肿瘤生长抑制相关，其在肿瘤发生中的作用和机制得到了更好地阐明。总结MEG3的功能及在肿瘤发生中的研究进展。 |
| 中文关键词:长链非编码RNA 人母系表达基因3 表观遗传 肿瘤 抑癌基因 |
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| Research progress of lncRNA MEG3 in tumorigenesis |
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| Abstract:Long non-coding RNA (lncRNA) covers most of the messages from the human DNA without protein-coding potential,which is a wide range of complicated molecules that consist of more than 90% of the whole genomic and present in different forms in the course of pathophysiology of cancers.In 2003,lncRNA MEG3 was firstly discovered as a potential tumor-inhibiting factor of pituitary adenomas.Later on,the roles and mechanisms in the regulation of gene expression,imprinting,transcription,and post-translation of MEG3 in meningioma,hepatocellular cancer,lung cancer,neuroendocrine tumor,prostate cancer and other kinds of tumors were further clarified,indicated that the expression of MEG3 was down-regulated or deficient in a wide range of tumors while the expression up-regulation of MEG was greatly correlated with tumor inhibition.The function of MEG3 and its research progress in tumorigenesis were summarized in this paper. |
| keywords:lncRNA MEG3 epigenetic regulation tumor antioncogene |
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