| 代谢组学在白血病中的研究进展 |
| 投稿时间：2019-01-12 修订日期：2019-06-21 点此下载全文 |
| 引用本文：宋志强,朱臻宇,刘悦,柴逸峰.代谢组学在白血病中的研究进展[J].药学实践杂志,2019,37(5):385~389,399 |
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| 基金项目:国家自然科学基金（81703674） |
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| 中文摘要:代谢组学是对生物系统（细胞、组织、器官、生命体）中所有内源性小分子代谢物进行定性和定量分析的一门新学科，通过研究代谢物和代谢通路改变与生理病理变化之间的规律，揭示疾病的代谢本质。白血病是一种常见的血液系统恶性肿瘤，它的发生发展与代谢密切相关，代谢组学发现的内源性小分子代谢物已经广泛应用于白血病的发病机制、诊断和药效机制研究并取得了显著进展。综述近年来代谢组学在白血病发病机制、诊断和药效机制方面的研究进展，以期为进一步研究提供参考。 |
| 中文关键词:代谢组学 白血病 内源性小分子代谢物 发病机制 诊断 药效机制 |
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| Research progress of metabolomics in leukemia |
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| Abstract:Metabolomics is a new science to quantitatively or qualitatively analyze all the endogenous small molecule metabolites in biological system(cells,tissues,organs,living organisms),which reveals the metabolic nature of diseases by studying the laws between changes in metabolites and metabolic pathways and physiological and pathological changes.Leukemia is a common malignant tumor of the blood system,which occurrence and development are closely related to metabolism.Endogenous small molecule metabolites discovered by metabolomics had been widely used in the study of pathogenesis,diagnosis and pharmacodynamic mechanism of leukemia and made significant progress.The advances of metabolomics about the study of pathogenesis,diagnosis and pharmacodynamic mechanism of leukemia in recent years were reviewed in this paper in order to provide reference for further research. |
| keywords:metabolomics leukemia endogenous small molecule metabolites pathogenesis diagnosis pharmacodynamic mechanism |
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