| Th2相关炎症因子在湿疹发病中的作用机制 |
| 投稿时间：2018-09-28 修订日期：2018-11-20 点此下载全文 |
| 引用本文：朱聪聪,潘会君,朱全刚.Th2相关炎症因子在湿疹发病中的作用机制[J].药学实践杂志,2019,37(1):9~13 |
| 摘要点击次数: 1225 |
| 全文下载次数: 716 |
|
| 基金项目:上海市科委资助项目（17401901800） |
|
| 中文摘要:湿疹是临床常见的炎症性皮肤病，具有剧烈瘙痒、反复发作等特点。其病因复杂，包括多种内、外因素相互作用。主要发病机制与Th2免疫应答失衡有关，相关的炎症因子更是发挥十分重要的作用。上皮衍生因子胸腺基质淋巴细胞生成素以及白介素-33（IL-33）能够引发Th2免疫失衡，促进IL-4、IL-5、IL-13等炎症因子分泌，后者进一步诱导嗜酸性粒细胞增多、IgE生成。综述Th2相关炎症因子在湿疹发病中的作用机制，对湿疹治疗具有重要意义。 |
| 中文关键词:湿疹 炎症因子 胸腺基质淋巴细胞生成素 白介素-4 |
| |
| Mechanism of Th2 related inflammatory factors in the pathogenesis of eczema |
|
|
| Abstract:Eczema is a common clinical inflammatory skin disease characterized by severe itching and recurrent attacks.Its etiology is complex, including a variety of internal and external factors.The main mechanism is related to the imbalance of Th2 immune response, and related inflammatory factors play an important role.Epithelial-derived factor like thymic stromal lymphopoietin and interleukin-33 could trigger Th2 immune imbalance and promote the secretion of type inflammatory factors such as interleukin-4, interleukin-5, and interleukin-13.These inflammatory factors will further induce eosinophilic granulocytosis and IgE formation.In this paper, the research progress of mechanism of type 2 related inflammatory factors in eczema were reviewed, which provided the great significance for treatment. |
| keywords:eczema inflammatory factor TSLP IL-4 |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
