| 超重可能是急性高山病的危险因素:一项Meta分析 |
| 投稿时间：2018-03-20 修订日期：2018-07-03 点此下载全文 |
| 引用本文：熊娟,鹿辉,王荣,贾正平.超重可能是急性高山病的危险因素:一项Meta分析[J].药学实践杂志,2018,36(5):433~437 |
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| 基金项目:全军后勤科研项目（CWH17J012）；国家自然科学基金资助（81401552） |
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| 中文摘要:目的 超重也许是急性高山病（acute mountain sickness，AMS）的危险因素，但仍存在很多争议。因此，进行Meta分析研究超重在AMS发生中的作用。方法 利用电子数据库系统检索研究超重与AMS相关性的文献（截至2018年2月28日）。利用Mantel-Haenszel随机效应模型进行数据整合。纳入文献的异质性由I2的值表示。以P<0.05为具有显著性差异。用Revman 5.0软件处理和分析数据，结果以95%置信区间森林图的形式表示。结果 纳入研究的566名超重志愿者中有300名患AMS（53%），而1 006名非超重志愿者中只有338名患AMS（34%），超重志愿者患AMS的危险比率（risk ratio，RR）为2.02（95% CI 1.08~3.76，Z=2.21，P=0.03）。结果表明超重是AMS发生的一项危险因素。结论 虽然需要进一步深入的研究来确认超重在AMS发生中的作用，但根据有限的研究提示，超重也许是AMS发生的危险因素。因此，超重个体在进入高海拔地区前，应当做好充分的预防措施来避免AMS的发生。 |
| 中文关键词:超重 急性高山病 荟萃分析 |
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| Overweight might be a risk factor of acute mountain sickness: a Meta-analysis |
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| Abstract:Objective Overweight might be a risk factor of acute mountain sickness (AMS) but its efficacy on developing AMS remained controversial. To study the role of overweight in AMS by a Meta-analysis. Methods A comprehensive literature search (last update, February 28th 2018) was carried out by searching electronic databases for full texts of studies which compared incidence of AMS in overweight with non-overweight individuals. The primary outcome measure for this meta-analysis was the incidence of AMS. Mantel-Haenszel random effect model was used to aggregate data. Heterogeneity of included trials was interpreted by I2 values. A α level of 0.05 was used as the level of significance. The results were reported in a forest plot with 95% CI. Revman 5.0 software provided by the Cochrane Collaboration was used for data processing and analysis. Results AMS occurred in 300 of 566 (53%) in overweight individuals and in 338 of 1 006 (34%) in non-overweight individuals. Compared with non-overweight individuals and independent of the baseline risk ratio (RR), the combined RR of developing AMS in overweight individuals was 2.02 (95% CI 1.08 to 3.76, Z=2.21, P=0.03). It was suggested that obese was a risk factor for developing AMS. The five included studies had high heterogeneity (I2=94%). Conclusion Although further in-depth studies were needed to confirm the function of overweight in the development of AMS, according to a limited number of studies, overweight might be a risk factor of AMS. Therefore, overweight individuals should be provided adequate prophylaxis against AMS before ascent to high altitude. |
| keywords:overweight acute mountain sickness Meta-analysis |
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