| 五味子酮衍生物的合成与抗氧化活性研究 |
| 投稿时间：2017-09-29 修订日期：2017-10-19 点此下载全文 |
| 引用本文：王鹏儒,李伟,彭雪米,郑巍,郭良君,金永生.五味子酮衍生物的合成与抗氧化活性研究[J].药学实践杂志,2018,36(2):112~115,135 |
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| 基金项目:国家自然科学基金资助项目（20502034）；原南京军区医学创新课题重大项目（14ZD02） |
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| 中文摘要:目的 设计合成五味子酮衍生物，并测试其体内抗氧化活性。方法 采用酰化等方法合成了10个五味子酮衍生物，其中7个为首次报道，同时测试合成的化合物对小鼠血清中超氧化物歧化酶（SOD）的影响，分析构效关系。结果 化合物2、3、5和8可明显提高SOD的活力，其中化合物2、3、5的作用明显优于五味子酮。结论 五味子酮衍生物具有良好的抗氧化活性。构效关系表明，五味子酮结构中1位的羰基和2位，3位的甲基不影响五味子酮的抗氧化活性。 |
| 中文关键词:五味子酮 合成 抗氧化作用 |
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| Synthesis and anti-oxidation activity of schisandrone derivatives |
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| Abstract:Objective To design and synthesize schisandrone derivatives for the therapy of disease like AD,and to measure their anti-oxidation activity. Methods Ten compounds were synthesized,and seven of them were first reported.The influence all the compounds on SOD from the mouse serum were measured to evaluate anti-oxidation activity.Structure-activity relationship (SARs) were also discussed. Results Compounds 2, 3, 5 and 8 could increase the activity of SOD in mouse serum.Furthermore,Compounds 2, 3 and 5 showed better activities than schisandrone. Conclusion Synthesized schisandrone derivatives showed anti-oxidation activity.The SARs demonstrated the carbonyl of C-1 position and the methyls of C-2 and 3 had no influences to the anti-oxidant activity. |
| keywords:schisandrone synthesis anti-oxidation |
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